I'm like so bored!
Yeah me too!
Hey! We should build a bridge to the clouds!
But that's like alot of work.
We should do something totally amazing and awesome like a make over!
That is such a good idea! Except, I don't like make up.
We should make something, like cure cancer!
But like, I want to do something for me.
What is that?
Maybe it's a blade coming out to get us!
Or it's a flying saucer!
Wait a minute.
Wow! You guys are dramatic.
What is that?
Oh that?
These are my fidget spinners.
What's a fidget spinner?
Well, let me tell you.
Are you a nerd?
No!
Are you a loser?
No!
Well fix it all with a brand new fidget spinner.
Wow!
Woah!
I'm cool!
Let me try!
Be careful Batgirl!
It can't be that cool.
Haha! I love fidget spinners.
Keep watching for our secret after scene!
And don't forget to check out our instagram at superherokids7
For the winner of our fidget giveaway!
If you want to see more of our awesome videos just click the info card above.
Subscribe and we will see you next week for another epic superhero kids video.
For more infomation >> She Spins a Fidget Spinner and this happens! FIDGET SPINNER CRAZE Music Video! SuperHero Kids - Duration: 4:41.-------------------------------------------
Scott Galloway: Tesla's Biggest Innovation - Duration: 3:11.
Winner or loser? Tesla,
which is trading at almost six times revenue -
vs. Ford and GM at less than .4x.
In April Tesla surpassed Ford in market value despite selling 80,000 cars in 2016, versus Ford's 6.7 million.
Tesla's most revolutionary change of the auto industry is not its electric engine -
everyone's building those -
but its proximity to the consumer,
whether it's high-end malls where they own their own dealerships
or YouTube, where they are sucking all the oxygen out of the ecosystem.
How much does Tesla spend on traditional advertising?
Almost zero
because they've mastered the medium of PR and new economy platforms.
A winner?
Brands mining data about users' digital behavior to create innovative physical products.
Airbnb is launching a print travel magazine
using the most popular searches on its site to shape editorial coverage.
The first issue includes an article about Porvoo
because an increasing number of Airbnb users are interested in the Finnish city.
Interesting and Finnish - those are two words you don't often hear in the same sentence.
Similarly, transit app Citymapper is launching its own bus service in London
gleaned from data on routes that were popular but underserved by existing public transportation.
A winner: Apple,
which last week became the first company in the U.S. to cross an $800 billion market capitalization.
It also has a quarter of a trillion dollars in cash
equal to the GDP of Denmark -
and Denmark doesn't even have interesting cities like Porvoo.
What should Apple do with all that cash?
Launch the world's largest tuition-free university.
The education market is falling-off-the-tree ripe for disruption.
A sector's vulnerability is a function of price increases relative to inflation.
Education has been the same for five decades.
NYU charges kids, no joke,
$500 a minute for me and a projector.
How do I put this?
That is fucking ridiculous.
Apple could really put a dent in the universe -
or they could just build a better phone.
Losers: every apparel brand blaming Amazon for their woes.
As a matter of fact, fast fashion has added more to its top line in terms of revenue
than Amazon has added in the field of apparel.
The reckoning is here
but a lot of apparel retailers have themselves to blame
for poor merchandising, over-storing and not thinking about trends and being more adaptive to a declining supply chain.
I love fashion, but I don't follow fashion.
Fashion follows me.
That's right.
Today, a cross between aging skateboarder and fish that swam too close to a reactor.
Nailed it.
We'll see you next week.
-------------------------------------------
How to Impeach the President (Or Not) - Duration: 2:29.
Want to get rid of the president? Awesome.
First, find an impeachable offense:
What's an impeachable offense?
Treason, Bribery or "Other High Crimes and Misdemeanors."
Okay, so what's "other high crimes and misdemeanors?"
Nobody knows.
Some people say it means bad things only people in high office can do -
like misusing public assets or dereliction of duty
or getting a hummer under the Resolute Desk.
Others say it doesn't mean minor, everyday criminal behavior —
just really bad criminal behavior,
like lying under oath about getting a hummer under the Resolute desk.
Others say it's any crime or misdemeanor at all,
even if it has nothing to do with their their position of power.
Did you steal that pen from work?
Petty theft is a misdemeanor.
You are no longer President.
Government officials have been impeached for submitting false expense reports,
lying under oath, even showing up to work drunk.
It's a pretty wide net.
Of course, this is the highest office in the land we're talking about,
and considering all the shit presidents have done without being impeached,
it's a pretty high bar.
So to sum up: it's a wide net, with a high bar.
So once you get an impeachable offense,
get a majority of the house to vote for it and then go to trial in the Senate --
call witnesses, present evidence --
it's pretty much like a normal court case,
except the judge is the chief justice of the supreme court,
the prosecuting attorneys are members of the House,
and it takes place in the freaking Senate.
Then after a couple of months of the highest rated programming in CSPAN history,
the senators vote -- and if 67 senators find the President guilty, he's gone.
But what if there was another way?
Without all that messy law and order stuff?
The Vice President and a majority of the cabinet can invoke the 25th amendment
and present a written declaration to Congress
that the President is "unable to discharge the powers and duties of his office,"
Okay, what does that mean?
Well, in the past it's been used for things like "Hey, I'm getting a colonoscopy,
can you cover for me for a few hours?"
but now some people want it to mean "I just think this guy is an asshat."
Regardless of the rationale, once those articles are invoked, the magic wand is waved
and the President is immediately stripped of power.
No trial, no witnesses, no evidence, no votes -- just gone.
Of course the President is going to say "Hey, I'm totally fit for office,
get out of my chair"
but if the Vice President won't budge, then it goes back to congress,
which will have three weeks to decide who gets to run things.
This time though you need 2/3rds of the Senate and 2/3rds of the House
or maybe it's 2/3rds of the Senate and the House,
nobody really knows because it's never happened before
and it'll probably end up going to the Supreme Court anyway.
Regardless, if enough of them agree that the President is an asshat or whatever,
the Vice President stays put, and the President is never heard from again.
Or more likely he goes on twitter
and says this was an extra-judicial coup by Washington insiders
and starts a new civil war, only this time with bigger guns
and planes and bombs and stuff.
So maybe we shouldn't decide to get rid of a President just because we hate them
and then, afterwards, figure out how to pretend it's the law.
-------------------------------------------
The "Worst" Champion in League of Legends - Duration: 8:34.
What's up guys it's me Jeremy!
Throughout the history of the game, one of the biggest challenges the League developers
have faced, is how to balance things for Professional Play, while also balancing for casual play.
They have always taken both aspects into account when balancing and designing things, especially
champions, but quite often there are discrepancies that cause major issues in certain champions
or the meta.
One of the biggest examples of this is Ryze.
Statistically the worst champion in the entire game, Ryze has a win rate that sits at the
lowest of all of the league of legends champions currently across multiple winrate websites.
LoLKing, even places him at a winrate below 40% overall.
Looking only at the statistics and nothing else, Ryze would be considered the worst champion
in the game right now.
However despite being the statisticaly worst champion in league of legends, Ryze is certainly
not the worst champion in the game in terms of just about everything else.
And in fact, he is currently seeing competitive play.
Most recently, Ryze was used by Korean midlaner Maple at the Midsummer Invitational Tournament
in a game where he went 12/0/7 and undoubtedly carried his team to an overwhelming victory.
So despite being one of the worst statistical champions, Ryze manages to be one of the more
prominent mid laners in Professional Play, at least in Korea.
Designing a champion to be playable in both professional and casual play is generally
not a problem that occurs too often.
The large majority of league champions scale evenly in this aspect, if they are good in
pro play they are good in casual play and vice versa, and as a result a lot of casual
play champions are popularized by pro play.
But for some champions an inverse scaling can occur, where they can be amazing in pro
play, and horrible in casual play or vice versa.
Although there is no set guidelines or rules, there are a few major tendencies that these
champions who are much stronger in pro play typically have.
Again they are not completely decisive, but having a few or many of these traits tend
to make a champion much stronger in pro play, while also at the same time, much weaker in
casual play.
First and foremost, champions like this are always challenging to play.
It's no secret that the average casual player will likely struggle with a champion that
is on the more difficult side of things.
On the flip side though, champions that are harder to play typically have more outplay
potential, which means that when played at the absolute highest level of skill, they
are much stronger than they otherwise could be.
In the case of Ryze, his high mechanical difficulty, skillshot reliance, and overall skillset does
tend to be on the more challenging side of things.
Ryze is far from the most difficult champion in the game, but he's certainly not easy
to play.
In addition, these champions are often heavily reliant on their team.
Team strategy and team-based gameplay is something that will be a huge crutch for a champion
in solo queue, because you just can't rely on your team as much in that type of setting.
Whereas in pro play as you would expect, these team based strategies can shine through immensely
and become incredibly powerful.
This is definitely where Ryze fits in.
With his Ultimate, it can be a completely game changing tool if your team can use it
properly, but in soloqueue, teams just don't have the coordination to utilize the ability
to it's maximum potential.
You could be the best Ryze player in the entire world, and you will still have a much harder
time in soloqueue than you would otherwise, because you will be missing that coordination
that is so crucial to making his ultimate work at its maximum potential.
And the third major thing that can define a champion in this area of design are their
weaknesses.
Now this is a design trait that is much more likely to make a champion bad in professional
play but good in soloqueue rather than the other way around, but there are a few that
can benefit from this, and I would make the argument that Ryze is probably one of them.
His combos allow for a ton of versatility and utility that give you something for any
situation, both aggressive and defensive.
But probably the most iconic benefactor of this design trait was Azir… at least before
he got nerfed a bunch of times.
Azir was a champion that when played to his fullest potential, really had no weaknesses.
Or at least he wouldn't on paper, because if he was played perfectly, his kit was so
incredibly versatile, that he could be played in a way that completely negated the supposed
weaknesses of his kit, to the point where he would become unstoppable.
So I guess really the better way to think about this is the more versatile a champion
is, the better they will be in professional play, but at the same time, being more versatile
does not help a champion succeed in soloqueue because the casual players are on average
unable to make the most of that said versatility.
These three major focus points of design in a champion's gameplay are typically what
shapes the difference in strength for pro versus casual play.
But at the end of the day, what's really important to us, is how casual play is effected.
Riot has always had the approach in balancing that nothing is allowed to be outrageously
overpowered in any circumstance.
And since they take both casual and pro play into account when balancing, when a champion
like this dominates professional play, they are inevitablely going to get nerfed, and
as a result become completely unplayable for the casual player.
And this causes a lot of issues for a lot of champions in
casual play.
And it's an issue that the developers have struggled with for a long time on quite a
number of champions.
Unfortunately, the solution, although it is quite clear cut, is not a great one.
The only real way to solve this issue for a champion, is of course with a rework.
And unfortunately, this is something Ryze is going to need if he wants to have this
issue solved for him.
The problem is just that these things stem from the gameplay, the mechanics of a champion,
rather than their numbers, so there is no real way to nerf or buff them without making
them extremely overpowered in professional play, or making them completely unplayable
in casual play.
But believe me when I say that Riot definitely understands this, and it's precisely why
we are seeing a ton of what are essentially mini-reworks to champions.
Especially in the last year, there has been a massive increase in riot changing and tweaking
mechanics and ability design, rather than buffing or nerfing numbers.
When I see a change to a champion that influences their mechanics, for better or for worse,
it makes me a lot more excited than a change that just gives a champion plus or minus 5
AD.
Because although these mechanics changes may not always be the best, they are certainly
necessary to experiment with when trying to solve issues in gameplay.
In an ideal world, every single champion in the game should be playable in some form of
niche in both professional and casual play.
However, it just so turns out, that it's going to take a lot of reworks for us to get
there.
Thanks for watching.
This video was part of a series I will be doing where I attempt to highlight and explain
the more complex and underappreciated design aspects of League of Legends.
So leave a comment and let me know if there is another mechanic or design concept you
would like me to take a look at.
Either way I hope you have a wonderful day, and I'll see you guys next time.
-------------------------------------------
Reading Your Fan Mail 😱😂 - Duration: 14:08.
Mister Postman look and see
is there a letter in your bag for me?
We've got a post box and Vagabuddies
are sending things to us.
Anyways, you've got it.
What's going on friends of the internet,
Vagabuddies?
We gave you guys....
A while back we gave you our P.O. Box,
and some of you amazing human
beings have actually sent us stuff.
This is us, sitting down, opening
the packages that you sent and reading
all the cool postcards.
It's really cool to have a P.O. Box.
We've never really opened one before.
It basically allows you to send us anything
that you want. We can get packages;
we can get letters,
We've got a mixture of both.
First one comes from
Chicago, Illinois and has an
awesome Batman postmark.
It's called a stamp. Oh, that is called
a stamp. Yeah.
I recently found out that we are both
considered what's called an older millennial
because we were born after 1989,
and we remember things like mail
and before smart phones.
What do you mean after 1989?
You were born in 1986. Oh before
We were before 1989,
and that's the big shift.
He doesn't even remember when he was born
Opening this one up
It's got a lot of pictures from
from Norm
It says pictures taken during my trip
to India in 2016. Cool
At the top it says happy holidays
and thanks for encouraging us to
keep exploring. A heartfelt
wish to you for more fun and
life changing adventures in the new year.
Cool. This was sent in December.
It says wishing much love. Namaste.
Very cool.
These are some nice photos, Norm.
Hold them up to the camera.
Your breath smells like tuna, dude.
Tuna? [blows breath] Ugggggg
Smells like coffee, Bro.
Umm....India.
We've been talking about it a lot.
We've been hinting at it a lot.
We're going to hint at it a little bit more.
Fall 2017
Vagabrothers Do India.
This looks like a great trip.
I hope you had fun.
Wishing you much love and namaste.
This is from the new year marked Jan 2, 2017
That is a view of Huntington Beach Pier
Coming from Huntington Beach, which
is not far from us, as the crow flies,
we have a letter from Erin.
She says, "Happy New Year."
I hope this finds you well.
I love watching all your videos
and appreciate the professional quality in them.
I'm going to study abroad in Ireland
so your videos from there are really
helping me plan some trips around the country.
Awesome. I hope you have fun in Ireland.
What a great place to study,
although I don't know how much studying
I can get done with all that Guiness
floating around me.
There's no better excuse for sitting in
a pub than studying.
Where are you going to be studying?
Galway? Trinity College? Dublin?
Let us know in the comment box.
Good luck with the semester abroad, Erin.
Thank you.
Next up... so this one.. whoa... crazy
sunset from Guam in the South Pacific.
Is it in the South Pacific? It is.
Or is it the Pacific?
My name is Paolo, and I was born and raised
In the Pacific Island of Guam,
but I currently attend university in San Diego
No way. We're from San Diego.
We are from San Diego.
I'm a new subscriber to your channel,
and I think your content is so unique
and inspiring.
Wish you all the best in 2017, and stay curious,
keep exploring, and I'll see you on the road.
That's awesome. Yo, Paolo.
Thank you very much for this letter.
We appreciate the support, obviously.
We hope you enjoy San Diego.
Let us know how you're liking our home town.
What's your favorite craft brewery from SD?
What's your? Difficult question.
I'm really liking Alpine Brewery.
It's in San Diego County. They make a
great IPA, and they have a really good hops.
Society's from San Diego? North county
I like Society.
Just because it's called Piney
No just because it has a French name.
I like the culture.
I like the culture.
But the French do not make great beers.
It's true. I'm sorry.
Je suis desole. The Belgians
Au contraire, mon frere.
Les gens de Belgique.....
{make a superb beer}.
Superbe. Fantastic.
Speaking of French words...here we are.
Des Moines, Iowa
It sounds.. I guess it's French.
That's where all the fur trappers were,
the Great Lakes region,
all the Ohio and Mississippi basin.
Great. Can you read the letter, please?
Yes. We have a letter here from Madison.
He says, " Hi, all. I just stumbled upon
your channel, One of the first videos I
saw was giving out your P.O.Box".
It's cool. It's how we get this.
Madison says, " I love it when the world
reminds me that it is small.Now I've
watched a series of videos, and I'm loving them.
I've always been collecting postcards
and I love hand written correspondence".
She says terrible hand-written correspondence
" I love terrible hand-written correspondence".
For almost a year, I've been writing myself
postcards daily, and recently begun
sending postcards to friends, family , and
new people I've never met.
This is postcard number 19.
Very cool. Madison, thank you for the card.
Madison has asked us to take a photo
of this card.
How about putting it into the video instead?
There's your card. Thanks, Madison.
This one looks like it's coming from.....
Stuttgart in Germany.
Ja...this is a very nice little card.
Hey, I've just discovered your channel
in 2017, and ever since I have been
obsessed with your videos.
I have already travelled all over the world,
but you guys inspire me to never stop.
Sttutgart is where I have lived for the past
6 years with my family.
I thought it was really cool when you
toured the Andechs Cloister, only a couple hours from here.
That's my dad's favorite beer.
He even bought a set of their glasses.
Maybe I will see you guys on the road one day.
Elizabeth. Thank you for your card
Please tell your dad that Andechs
is one of the best breweries I have......
anytime I see Andechs
on a beer menu, I order it because
those mugs, they do it right.
They've been there for hundreds of
years, and their beer is on point.
We go to Berlin once a year,
and we go to a little Bavarian style
spatzle and beer place,
and we order Andechs there.
Right around our house here in Venice
is a German-style restaurant and beer
garten called Wurst Kuchen.
I don't know how to pronounce it.
They serve Francis Conner, which I
think is a great, great wheat beer.
Another monk brewery. Yeah.
Danke Schon, Elisabet.
Who's next?
Now we have two beautiful postcards
from Fiona. Fiona......
I'm not sure where you're coming from
because when you write postcards,
it doesn't say where they came from.
Por avion. I think it's French. Oh!
Canada. She's French Canadian, maybe.
Possibly. Just a reminder. When you're
sending us postcards, tell us where you're
writing from because postcards don't
always have return addresses, so we're
not sure. Anyways, we got two beautiful
postcards here from Fiona, who's
writing to us from Canada.
Look at them right there: one of Spain;
one of the world and very cool because
it has shipping routes, which I think are
really awesome things to have on maps.
Fiona says she's part of a website called
Post Crossing. You send
postcards in snail mail all around the
world. Can you stop saying snail mail?
Why? Because it just makes me think of a
snail trail, and just no. You are perverted.
Fiona says, " Hi. I'm part of a website
called Post Crossing.com. You send
postcards in snail mail all around the
world. If you guys are interested, check
it out."
I did check it out, and it seems really cool.
It's a way of matching you with a random
person all around the world, like a pen pal.
If you're into that, go check it out,
and thank you for the tip, Fiona.
Beautiful postcards.
I love this one from Spain.
Spain and Portugal.
The Iberian Peninsula is such a special
place to us, one that we need to get back
and explore and make more content
because all we've really done is
the Basque Country.
Vale..Vamo
Next up we have.....
it says fishin' not wishin'
Fishing in the Ozarks.
The Ozarks, man. Ozark Mountains.
Isn't that? No, it's the Blue Ridge Mountains.
This is from the Ozarks in ....
He's writing from Jefferson, Missouri
It says the Ozarks in central Missouri
is one of the nation's premiere fishing
spots for a wide variety of fresh water
species, including black bass, white bass,
crappy, cat fish,
wall eye, striped bass and blue kiel.
Hello Alex and Marko,
Your Youtube channel is awesome!
Please keep up the good work :)
From Ali Ratzel. Thank you, Ali.
I think it's Ali, Ali. It's A-L-I.
It says Mister.
Oh. It does say mister, so it's Ali`
Thank you, Ali....A-Li`
Thank you, Mr. Ratzel for your card,
short, sweet, and to the point.
We appreciate it, and we will keep
up the good work.
Good luck fishing. Ready?
Best of one. Rock, paper, scissors.
Rock, paper, scissors.
Destroyed. I get to open the package.
These are those little sesame treats, bro.
OMG. This is awesome.
Who sent this? I'm so glad I won this one.
I won this opening package.
And a letter.
This is amazing. We have a ton of
sesame candy. We have red and gold,
which is I think for Chinese New Year.
We're going to see. This was sent in January.
First up, I want to say thank you, thank
you for inspiring me in so many ways by
sharing the world through your perspective.
Your stories have inspired me to get out
and be more adventurous, be more
curious, and just get out there. Epic.
All CAP
Amazing. She's been following us since
the BBB TV ( Biggest Baddest Bucket List}
which is 2013. Says she'll never forget
when we ate a sheep's head. Lol
Disgusting. Neither will we.
The quality of your videos are so professional,
I can tell all the hard work, love,
attention, and detail you put into it.
Thank you so much.
I honestly feel you are my personal tour guides.
I get mad wanderlust every time I watch
your videos. That's awesome.
Favorite series from you guys is
the Basque Country. Epic.
Love that place.
Get this.....
She has sent us an origami pagoda
that says, "Stay curious, keep exploring"
in Chinese. Wow!
Thank you very much.
What do we say in Chinese?
So thank you very much. We appreciate
the Chinese culture.
Stay curious, keep exploring.
We're going to eat
not peanut butter, but good.
Do you know about the ginger chews?
These things are amazing.
Last but not least.
It came today.
This one came today.
It looks like it's an outline of Latvia
with a bunch of Latvian words.
Maybe they're cities. Looks like it.
Riga is circled.
It says Latvia.
Nice place.
Is that the Borat voice?
No, this is. Nice place.
The ginger candy. Hold up.
So good.
Dear Marko and Alex, hope you guys
are doing great and hope Marko had a
great birthday. I did. Thank you.
Today I got an idea, just a thought.
Why don't you guys do a video on the
Coachella Festival?
I've always wanted to go there.
It's still on my bucket list, but I never
got the time because I'm still studying.
We've never been to Coachella, either.
Maybe next year.
We always ay that. I want to go.
I want to actually go. Cool.
Thank you, Mahema from Latvia.
Beautiful little bird on the stamp.
Thank you very much.
Next one up is from....IRS
From the IRS? Let's not look at it.
Deal with that later.
Ladies and Gentlemen, Vagabuddies,
thank you very much. I'll eat it afterwards.
As you can see, you're chewing.
You can't speak and chew.
While Mark's chewing,
I will thank all of you.
Ladies and Gentlemen, Vagabuddies
from around the world, thank you very
much for taking the time and effort to
write us these lovely little cards.
Stefanie, thank you for sending all these
amazing sesame treats and the origami.
Pretty cool stuff.
We really like the idea of sending
food like this to us.
if you're from a country that has really
specific stuff like candy, snacks, send
us a package of it.
If you give us enough stuff,
we can make a video about it.
Maybe we'll do tasting Mexican sweets.
Maybe tasting stuff from India, whatever.
Make sure it can get through customs,
and if it does,
we'll do our best to include it in the video.
If you enjoyed this video, you know what
to do: give it a thumbs-up; share it with
your friends, and subscribe if you haven't
already. And.......
in the meantime, stay curious,
keep exploring, and we'll see you guys at
the post office.
Hey, Mister Postman. Peace.
Later.
-------------------------------------------
Sources: Lieberman is FBI director frontrunner - Duration: 1:35.
For more infomation >> Sources: Lieberman is FBI director frontrunner - Duration: 1:35. -------------------------------------------
Sneak Peek: The Greatest Prize Of All | Season 8 | MASTERCHEF - Duration: 1:10.
I can't leave here without being the next Master Chef.
I'm here to win.
There's no other option.
Welcome to the one and only "Master Chef" kitchen.
Yeah, baby!
You are the top home cooks in all of America.
America's next "Master Chef" is standing in front of us
right now.
And with that title comes incredible prizes.
For starters, a quarter of a million
dollars and a guaranteed spot on the next "Master Chef" cruise.
Yes.
And of course, there's the greatest prize of all,
the "Master Chef" trophy.
I'm gonna show these judges what true Oklahoma
cooking's all about.
Let us down and you will be going home.
Show us you want that apron, ladies.
Your 60 minutes starts now!
-------------------------------------------
Rob Reiner on the Burden of His Name - Duration: 2:07.
I didn't feel the pressure from my father,
I felt the pressure internally because my
father had achieved at such a high level
that I thought "well, I don't know if I'll
ever be able to, you know, break through."
[MUSIC]
Everything that you experience in life
informs everything you do.
I mean, I grew up in a show business family.
"How many children do you have?"
"I have over 42,000 children.
And not one comes to visit me!"
[LAUGHS]
The funniest people in the world
came in and out of my house,
making people laugh, also
telling stories.
I tried to find ways to marry those things.
That all has to do with the way in which
I was raised, you know, all the things I've been
exposed to my whole life.
I had kids late in life, in my 40s,
and I thought, you know, this will be good,
because by the time they're of age,
I'll be a has-been.
But it didn't work out so much that way,
so that they have the double-whammy of their
grandfather and their father
if they wanted to go into the same line of work.
My oldest son Jake is a broadcast journalist,
so he's been drawn to that, and he also
does improv acting, so they're either gonna
you know, embrace it or reject it,
whatever they decide.
I just want 'em to be happy,
whatever they want to do.
When I was about eight years old,
and I'm told this, because apparently I went to my
mother first, and then she took me to my father,
and I said "Dad, I want to change my name",
and he was like, "Oh my God,
this poor kid at age eight is already feeling the pressure
of being Carl Reiner's son",
and he felt so bad, he says, "Well, what do you want
to change your name to?" and I said, "Carl."
I just wanted to... I wanted to be like him!
[MUSIC]
-------------------------------------------
Emily Ratajkowski Has All The Right Proportions | TMZ TV - Duration: 1:13.
EMILY RATAJKOWSKI, SHE WAS IN
FRANCE FOR THE CANNES FILM
FESTIVAL.
TODAY SHE WAS HANGING OUT IN A
BIKINI IN HER HOTEL AND SHE
LOOKS AMAZING.
WOW, LOOK AT THAT.
SHE LOOKS RIDICULOUS.
SHE'S PROPORTIONED.
SHE'S DEFINITELY THE BEST
LOOKING PERSON IN THE WORLD.
IN HER WEIGHT CLASS.
THERE ARE WEIGHT CLASSES FOR
MODELS?
IF YOU LIKE THEM THICKER?
BEST LOOKING HEAVYWEIGHT?
ASHLEY GRAHAM.
ASHLEY GRAHAM?
IT DEPENDS ON WHAT YOU CALL
HEAVYWEIGHT THOUGH.
DO NOT CALL HER A
HEAVYWEIGHT!
THAT IS SO OFFENSIVE.
IF THERE'S A WEIGHT CLASS FOR
MODELS, I THINK YOU'RE GETTING
IN DANGEROUS TERRITORY.
WHY?
THEY'RE NOT GOING TO LIKE IT.
AND PEOPLE DON'T LIKE TO BE
CALLED SKIRTY, VAN.
OR THICK.
I'M TRYING TO GET BACK DOWN
TO THICK!
[LAUGHTER]
-------------------------------------------
FC SCHALKE 04 ESPORTS - LIFE OF PRO'S - CIHAN YASARLAR - Duration: 6:13.
My name is Cihan Yasarlar - welcome to Berlin!
This is my elementary school. From 1st to 3rd class I was in this building on the left.
After 3rd grade I moved to the older building. This is the newer one over there is the older one.
There was the gym were we did sports 2 or 3 times a week.
This is the area were we played football a lot. We set up 2 goals and played football for hours.
Such a good time it was, before I had a career in esports.
I spend so many years here going to school and playing football - a lot of good memories.
This is were we played table tennis. Of course in the first few years we played a lot in the sand.
I miss the time back then, everything was easier. As you get older you get more responsibilitys.
I am very happy that I grew up here, it was a very happy and joyfull time.
You guys want to play some football? *kids* JAAAAAA!
This is were I spend most of my days. Nice little pitch with 2 goals, we really played a lot here.
There is a playground right here, lots of people today becaus it's warm outside today. Around 22 dagrees.
Nowadays kids want to have photos with me.
The bigger pitch is just 50m away but when it was to crowded we played here for the most time.
Really realy good old times.
Kids know me of course, I am relativly huge on social media by now and had a lot of succes recently.
Really just natural to get recognized then and it makes me feel really good.
It really means a lot to me. It shows I am foing something right and be a role model for them.
It's such a nice feeling getting those kind words from the kids and them being happy to take a photo.
They proudly show them around to there friends or post them online. Really really great feeling.
Living. Good place to live basicly. Over there is a nice turkish bazaar. I like it here.
Nothning you can't d in Berlin really. Go clubbing, into bars, have dinner. Everything really.
Many football cages as well - I really appriciate it here.
I do things like that very often with my friends. Have cold drink, have a snack whenever the time allows it.
It all started with me beating every friend on FIFA. I was the best player in my area back then.
In 2015 I visited the IFA and met a guy called Yaya. He was promoting a station were you could play FIFA.
I took him on a couple of matches and won all of them. We then stayed in touch and played online.
After winning online a couple of times he introduced me to his friends from the FIFA Scene.
One of those freinds was Joshua Begeher. He took care of me and I kept on playing online tournaments.
He introduced me to the world of Esports basicly. I kept on training hard and wanted to win everything.
Joshua got me into SK Gaming at first and later to were I am today, Schalke 04.
It really means a lot to me to represent a big club like Schalke in germany and the rest of the world.
Back then I had the PS1 and both games, FIFA and PES. Not at the same time, alternately.
Must have been 99' so as you can see I had a passion for gamiong from a young age.
FIFA turned out to be the better game over the years. So I stayed with it in the end and got better at it.
I never played as much as recently but today it is basicly my Job from wich I pay my bills.
I thought I really made it after the deal with SK. I thought to myself now you achieved something!
I was so proud being in an organisation at first, the big step to join Schalke was amazing for me after all.
I put everything on FIFA to achiev big things and win titels. I think I do just that at the moment.
Even though Paris was the first big international tournament for me I knew I can win, and i did.
-------------------------------------------
3ABN Today Family Worship - "Scripture Affirmations" (TDYFW017007) - Duration: 58:30.
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Summer Lookbook (Sub. Spanish) with Janiushka's & others - Duration: 3:29.
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Charlamagne "Pulls Up On Amber Rose and Disses Tyga Says His Music Is Trash" - Duration: 1:36.
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Feeling Lost? - Figure out what to do with your life! (Life & Career Self-help) - Duration: 4:22.
For more infomation >> Feeling Lost? - Figure out what to do with your life! (Life & Career Self-help) - Duration: 4:22. -------------------------------------------
How to Make Key Lime Pie - Easy Key Lime Pie Recipe - Duration: 7:24.
How to make Key Lime Pie - Easy Key Lime Pie Recipe
Hello and welcome back to In the Kitchen with Matt, I am your host Matt Taylor.
Today I am going to show you how to make Key Lime Pie, mmm yummy.
I had a request to make a video on key lime pie, so here we go, this key lime pie is really
easy to do, very few ingredients, sure to impress your friends and family, let's get
started.
First let's preheat our oven to 350 degrees F. Next what we are going to do is we are
going to take 3 egg yokes, add them to a large bowl, and we are going to take a mixer or
you could use a whisk or fork, and let's uh blend these up.
Okay about like that.
And now we have one can or 14 ounces, 396 grams of sweetened condensed milk, let's go
ahead and add that.
Use a spoon to come in here and get it all out.
All right we will go ahead and mix this together.
And now we want two teaspoons of lime zest.
Now how I get lime zest, is I have this tool it is called a micro plane, some times on
your, if you have a grater, you will have a little micro plane side to it.
But what you do is you take a lime, before you cut it and squeeze it, and you just go
across the planer here, and it will take off little shavings of the skin and that is called
lime zest, and it adds really good flavor to this key lime pie.
I will put a link down below to where you can pick one these up, if you want to pick
one up.
So 2 teaspoons of lime zest.
And then we are going to turn this on low and then we are going to gradually add 1 half
cup of fresh lime juice, now I squeezed a bunch of limes to get a half cup, or you can
buy already pre-squeezed key lime juice, freshly squeezed is always better in my opinion.
So on low and then we will just slowly add that lime juice, now there are other recipes
out there that have that add like an 8 ounce thing of cream cheese to this, but the classic
key lime pie does not have cream cheese in it, but it adds a different flavor profile
obviously, so that is an idea you can do as well.
So what we are going to do is I am going to take a graham cracker crust here, this is
just a pre-bought one.
It was on sale so I thought why not.
If you want to do a nice home made graham cracker crust, up in the right hand corner
there is a little eye, click on that, and it will send you a link to my cheese cake,
that has a nice homemade graham cracker crust, so take a look at that for a graham cracker
crust.
So what we are going to do is we are going to take our filling here, just pour it in.
This crust just happens to be a little bit bigger; it is a 10-inch, and this is meant
for a 9-inch pie, so it is not going to fill out quite as much, as it would if it was a
9-inch pie.
Go ahead and just spread it around.
Again this is a 10-inch piecrust, if you use a 9-inch, the elevation, of your key-lime
pie will be a little higher, but this will work fine.
Now we are going to go ahead and put this in the oven, and bake it for about 10 or 15
minutes until it just sets on top.
Traditional key lime pie is a no bake, but since there are eggs in here we want to just
go ahead and bake it.
All right so 10 to 15 minutes, all right, once we take the key lime pie out of the oven,
we want to let it sit and cool at room temperature completely, then we will put it in the refrigerator
for 4 hours to over night, so it completely sets up nicely for us.
All right once your pie has set for 4 hours or up to over night, now you are ready to
serve it just like this, or you could to like a meringue on top, or like what I am going
to do is I am just going to do whipped cream all on the top.
Now one thing you might notice I don't know if you can see this, you need to be careful
with your plastic wrap, if you cover it with plastic wrap to chill, because if it touches
the top, it will stick.
And when you pull it off it will leave it looking like this.
It's okay it is not going to effect the taste at all.
But it doesn't look as nice.
I don't really care because I am just going to put a bunch of whipped cream over it.
Just go ahead and put that on there.
Then I am going to garnish it with some limes, just for fun, just to make it look kind of
nice.
And there we go, key lime pie.
Now let's cut into this, and serve up a slice, got a little crumbly happening, that's all
right.
And there we go, awesome.
All right, our key lime pie is done.
It turned out amazing, it was really easy to do, very few ingredients, if I can do it
you can do it.
I am Matt Taylor this has been another episode of In the Kitchen with Matt, thank you for
joining me, as always if you have any questions or comments, put them down below, and I will
get back to you as soon as I can, thumbs up, down in the corner, push it.
Don't forget to subscribe to my channel and check out my other videos.
Take care, time for me to dive into this slice, oh yeah.
Mmm mmm mmm, super excited.
-------------------------------------------
Rare twin foals born in Bastrop County - Duration: 0:47.
ON OUR WEBSITE.JOHN:A BASTROP
COUPLE IS HOPING THEIR PETS
BEAT THE ODDS.THEIR HORSE,
SOPHIE, GAVE BIRTH TO TWIN
FOALS A WEEK AGO TODAY.JENNY
TUCKER IS SHARING THE STORY OF
BONNIE AND CLYDE WITH US.SHEY
SAYS SHE AND HER HUSBAND ALSO
CONSIDERED NAMING THEM SONNY
AND CHER -- BUT SETTLED WITH
BONNIE AND CLYDE- BECAUSE ONE
IS RAMBUNCTIOUS AND THE OTHER
IS MORE MELLOW.IT'S RARE FOR
TWIN FOALS TO MAKE IT PAST
BIRTH.BOTH ARE STILL AT THE
ELGIN VETERINARY HOSPITAL.WE
HAVE A LINK TO THEIR GO FUND
ME PAGE ON KXAN DOT COM A LONG
WITH A SLIDESHOW.
-------------------------------------------
DANIEL TIGER'S NEIGHBORHOOD | There Are Lots and Lots of Feelings | PBS KIDS - Duration: 0:54.
♪♪ There are lots and lots of feelings ♪
♪ How are you feeling today? ♪
- ♪ I don't feel good at all ♪
♪ I feel sad, sad, sad ♪
- ♪ And I feel mad, mad, mad ♪
- How do you feel? - ♪ I feel happy ♪
♪ My friends, my friends Oh, I feel happy ♪
♪ My friends ♪
- ♪ There are lots and lots of feelings ♪
♪ And we can feel them all ♪♪
- Wasn't that grrr-ific? -
-------------------------------------------
Ford B-MAX 100pk Titanium €4.000 korting! - Duration: 1:50.
For more infomation >> Ford B-MAX 100pk Titanium €4.000 korting! - Duration: 1:50. -------------------------------------------
Ford B-MAX 100pk Titanium €4.000 korting - Duration: 1:41.
For more infomation >> Ford B-MAX 100pk Titanium €4.000 korting - Duration: 1:41. -------------------------------------------
MR Imaging for Malignancy in Microcalcifications (June 2017) - Duration: 17:50.
[music]
Herbert Y. Kressel, MD Hi.
This is Herb Kressel and welcome to the Radiology podcast.
Today I'm joined by Dr. Pascal Baltzer who is Associate Professor of Radiology at the
Allgemeines Krankenhaus in Vienna and on the faculty of the Medical University of Vienna.
Welcome Dr. Baltzer.
Pascal A. Baltzer, MD Thank you Dr. Kressel.
It's great to be on line here with you.
Great.
Well Dr. Baltzer and his colleague authored a paper entitled "MRI for the Diagnosis
of Malignancy in Mammographic Microcalcifications: A Systematic Review and Meta-Analysis."
I found the paper quite interesting as it kind of moves us along the way of personalized
or precision medicine further refining how we might use our tools.
Dr. Baltzer what was the rationale for the study?
Why did you and your colleagues decide to look at this question?
Well the first idea was to really assess the diagnostic performance of breast MRI in general
because there was quite some discussion and controversies about that.
Very, very quickly we came to the thing that well actually we have to distinguish between
lesions presenting as microcalcifications on mammography and lesions not presenting
as microcalcifications on mammography.
The idea would be as my mammography office detects microcalcifications and that does
it very good and MR cannot detect microcalcifications whether MRI has any value here.
What we know on the other hand is that microcalcifications detected by mammography are not malignant
in the majority of cases so there's a huge potential to reduce the number of unnecessary
biopsies here and that was the reason why we focused on the specific entity of lesions
presenting as mammographic microcalcifications and yeah that's it.
I understand that having a biopsy is physically and emotionally traumatic, but on the other
hand it also resolves the question to some extent and so for some patients the extended
worry time where you have this suspicious finding is also problematic.
Why do you think that short term follow-up and biopsy isn't a good way to follow these
people?
Well the one thing is I think we are also talking of course now about health politics
because the time how long I have to wait for instance for the biopsy or the MRI depends
on how available those tests are and stand the possibility generally if the test is sort
of obviously I do not need another test if the patient waits like two months for it,
that's obviously clear.
However, it is really like that first the biopsy of course is (inaudible) which is quite
interesting.
In Austria the biopsy is more expensive than the MRI.
But of course that's insurance and health politics.
But, then the biopsy and especially the (inaudible) is the general standard of choice for biopsy
microcalcifications is quite invasive.
So although we do not have complications that need to be treated surgically, we have obviously
and at least I think in about 1/3 of the patients who have hematoma which even presents as a
lesion.
So the patient in both biopsy due to nonpalpable lesion, feels a palpable lump afterwards,
this is really a stressful concept.
I talk to patients that's one of the reasons why we think about using a non-invasive test
to clarify the situation here.
So you and your colleague performed a systematic review and meta-analysis, can you tell us
why you decided this route to try to answer this question and what exactly did you do
in your study?
My point of view before I'm doing one study is to check the literature of course which
I think should be obviously done and I in recent years have stuck to the procedure of
doing a systematic review and meta-analysis.
First to see whether something has been done already and then to get an impression how
heterogeneous the results are.
Are there other reasons why groups are performing better and non-better and what's the current
status on this and many cases there already has been enough literature or enough data
has been accumulated and so a meta-analysis for me is the first choice to assess the current
status and to identify fields and research gaps where we should work on.
I see.
And so when you looked at this problem, what did you think was the quality of the studies
that were available?
So basically we did a greatest assessment or greatest two assessment and found that
all studies we identified that there are 20 studies that met the inclusion criteria of
where actually that were applicable to result in research questions and just in some studies
we had a questionable risk of bias.
We had no studies where we deemed the risk of bias high.
Obviously and I personally think that always this risk of bias assessment has some problems
because the specific research question of course it warrants some specific methods are
not given.
For instance how the images are read, then of course there might be some bias, we have
to probe our sub-analysis.
So in this case we deemed the studies, after checking them, fully applicable to soft research
questions.
Although of course not all studies answer all the questions we were interested in.
Although your focus was sort of looking at the BI-RADS categories, not all the studies
actually reported BI-RADS category so how did you deal with that problem?
Is was really, first of all the inclusion criteria were studies that examined the value
of MRI to resolve or to diagnose malignancy in mammographic microcalcifications, and of
course we were interested in this sub-group so if the reason for referral, is it the BI-RADS
3 questionable whether there even should be BI-RADS 3 microcalcifications, BI-RADS 4 microcalcifications,
or BI-RADS 5 microcalcifications.
Again, the revised BI-RADS (inaudible) the questions that there is the BI-RADS 5 category
for microcalcifications.
Nevertheless, this study was first the first estimate the diagnostic performance of MRI
sensitivity and specificity for microcalcifications.
And then use sub-group analysis.
For instance due to BI-RADS refer categories in order to have the lesions stratified according
to the integrity, and of course also according to the prevalence of malignancy.
Okay so that by creating these sub-categories you could have sort of a more homogeneous
data set to kind of look at?
Yeah.
What were your key findings?
You looked at 20 studies, I think they had over 1400 lesions that were included and what
did you find?
So well the first and the most interesting finding is what also seems to apply in non-calcified
lesions, invasive cancer can be excluded with a negative predictive value of about 99%.
So there MRI is quite accurate.
That's what all MRI, what all I say fans of MRI always say since 20 years that their
MRI is valuable, it can exclude invasive cancer.
Regarding general malignancy, MRI does not perform that good.
The negative predictive value in general is about 90% which is good but not perfect.
But it is also quite specific so there's a solid diagnostic performance for all lesions
which is much better if I want to just exclude invasive cancer.
I see.
Okay.
Now you have a couple of interesting findings, but I wanted to ask you about the high heterogeneity
index that you identified.
In our journal we struggle with this.
Imaging studies are frequently very heterogeneous and my own experience with meta-analysis is
sort of like you were describing.
When you start kind of looking under the hood as we say all of the sudden you see a lot
of questions about what was reported, how terms were used and there is frequently a
lot of heterogeneity in the studies that we see.
How do you view this and how should readers who read the paper think about the heterogeneity
in the studies?
So first of all that's really probably the most important question.
First of all heterogeneity is really an issue as you pointed out.
Heterogeneity strongly hints at what we know that breast MRI is a bit more difficult to
interpret than the mammogram.
Training is not the same level.
It's not the same quality standards, and for sure we do not have the same diagnostic
criteria applied.
For instance, some authors may just use the presence of enhancement as a criterion and
if anything enhances we biopsy it.
Some authors we use more sophisticated criteria that will lead to a threshold effect meaning
that sensitivity may go down but specificity goes up.
We tried to answer this not so – generally if heterogeneity is too high, you and no one
should pool the data, should not give summary estimates.
What I think is most important is to identify subgroups that are less heterogeneous and
that was basically how we dealt with it and I think as the main question here was to exclude
malignancy, we just summed up the raw findings especially regarding missed cancers threat
by DCIS and invasive malignancies for every single study so every reader can have a view.
One of the main reasons for heterogeneity in this study, however, has not directly to
do or indirectly to do just with diagnostic performance that was the heterogeneous prevalence
of malignancy.
And if the prevalence of malignancy differs you add an order of magnitude in your heterogeneity.
That obviously says that not that the included studies and that is of course probably the
most important risk of bias that these studies did not include all the conflicted microcalcification
cases as they could, but some more better selected cases.
I see.
Now if I recall correctly that two things that were the take home lessons were that
MRI was particularly helpful for the BI-RADS 4 type lesions, perhaps you could speak a
little bit about that, but it was surprisingly not helpful for the BI-RADS 3.
So perhaps you could go into a little more detail onto sort of how you explain those
results.
Well regarding BI-RADS 4 I think that's the main entity of microcalcifications that
we would like to apply MRI especially as for instance if these are multiple lesions.
That's of course exactly the same reason why BI-RADS 3 microcalcifications may undergo
MRI because there may be several classes or even bilaterally so I want to know should
I or and then if so where should I do the biopsy.
I think the diagnostic performance of BI-RADS 3 microcalcifications and there are a lack
of data so this is a bit speculative, maybe these that these are microcalcifications that
do not look too suspicious and I think MRI is prone to miss of course a number of cancers
that do not enhance or just very subtly.
So if cancers enhance very subtly I will miss them if it's just a subtle enhancement and
this may be the case here.
We may discuss whether we reduce the number of over diagnosis here like it's a big discussion
in prostate MRI where they say well the lesions I do not detect by MRI are irrelevant.
I think there it's a common ground.
In breast imaging not that much, and then we have to limit that in BI-RADS 3 microcalcifications
the data was limited and even more heterogeneous.
In BI-RADS 4 microcalcifications; however, we found the best diagnostic indexes and again
also speculative because we scored two different sub-analysis.
In one sub-analysis we also found where we investigated the diagnostic criteria to apply.
We found that really the presence of enhancement is the most sensitive feature here.
So if I got the BI-RADS 4 microcalcification and there is no enhancement in the site that
actually should exclude cancer quite actually.
So that I think to be a very helpful finding in the right subgroup of patients, I agree.
Now the poor performance in the BI-RADS 3 do you think some of it is just inter-observer
variability in how they're using BI-RADS 3 or you didn't really have access to looking
at the microcalcifications in these patients?
Actually yes I always, I even remember one of the studies; I should not name it, which
was quite interesting.
I was just when I reviewed the paper one of those papers on BI-RADS 3 microcalcifications,
(inaudible) in many papers, the author said imaging examples.
They are example for the negative case was actually they pictured it, they printed the
picture, was a sublet; something we would call in mammography a minimal sign of malignancy.
So I think that it's about the criteria applied and I think especially in BI-RADS
microcalcifications it may be very difficult to – so that the community has not really
found a common set of criteria to diagnose malignancy here.
I think that's the main problem in BI-RADS 3.
Specificity also in our summary estimate, especially specificity was very low, so here
it may not be enough just to call any enhancements suspicious or absence of enhancement suspicious
because then I would do a number of unnecessary biopsies.
I think this is just an unresolved issue here.
Yes.
Thank you this is all very instructive.
Now have you changed your practice at the University of Vienna or do you have some further
research in mind to pursue this area of MRI in patients with microcalcifications?
What are the next steps for you?
Actually yes.
What we found in our meta-analysis was actually research gaps regarding the point already
outlined that is which microcalcifications or which patients with microcalcifications
will profit from the MRI scan and for instance which BI-RADS, it's BI-RADS 4 a, b, c, whatsoever
and what diagnostic criteria should be applied; and we are actually working on both fields
trying to do an MRI scan in any patients with microcalcifications scheduled for a very consistent
breast biopsy.
The thing in all centers we use specific situations that here really calls for the MRI, for the
problem solving MRI, they are covered by the official insurance systems and MRI is really
cheaper than the biopsy.
We are in a very lucky position here.
Good.
Well Dr. Baltzer I want to thank you for sharing the paper with us and for taking the time
to participate in the podcast.
It's been a pleasure speaking with you.
Thank you very much.
It was an honor.
Bye-bye.
Bye.
-------------------------------------------
WoW Legion PvP Gameplay Patch 7.2 - Ret Paladin DESTROYING Alliance in Twin Peaks! - Duration: 9:34.
WoW Legion PvP Gameplay Patch 7.2 - Ret Paladin DESTROYING Alliance in Twin Peaks!
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Patente del OVNI triángular es ahora de dominio público - Duration: 2:57.
For more infomation >> Patente del OVNI triángular es ahora de dominio público - Duration: 2:57. -------------------------------------------
vlc record 2017 05 18 20h35m54s TV 2 Danmark HD N Regionalprogram 20170518 193040 0000 ts - Duration: 2:39.
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Nissan Micra !! AIRCO 5 DEURS !! 1.3 SE N-CVT - Duration: 1:01.
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Bass Tree Farm Field Day | Farmweek | May 18, 2017 - Duration: 3:09.
GRAP
A TRADITION OF
SORTS WAS BACK
AGAIN IN SOUTH
MISSISSIPPI THIS
SPRING.
A NORMALLY QUIET
PINE STAND IN
MONTICELLO WAS
RECENTLY
TRANSFORMED INTO
AN OUTDOOR
LEARNING
EXPERIENCE FOR
SCHOOL CHILDREN.
ROLL MAP AND TAKE
FULL
THE BUBBA BASS
NATURAL RESOURCES
FIELD DAY WAS LAST
HELD IN 2010, BUT
RETURNED THIS YEAR
TO THE DELIGHT OF
LAWRENCE COUNTY
STUDENTS.
FARMWEEK'S
JONATHAN PARRISH
REPORTS.
[BASS FIELD DAY
PKG]
---PKG---
Fifth graders from
schools and
homeschools in the
Lawrence County area
were invited to the Bass
tree farm for some
hands-on education
about the great outdoors.
Many organizations such
as Extension and USDA-
NRCS were on hand to
help with the event and
teach the children the
importance of natural
resources and how to
maintain a healthy
environment. Students
took part in a variety of
activities during the field
day such as flying
through the air from a
rope swing, honing their
skills with a bow and
arrow and learning how
to make their own paper.
The field day is an event
that landowners Bubba
and Hortense Bass have
enjoyed hosting many
years. It started with just
one class and grew into
an annual event the
children look forward to
from schools all around
the area.
"It started in 2001 I
believe and it started
with Ms. Judy Grimes
class. She happened to
be teaching a resource
class in Monticello
Elementary. And so she
came to us and said our
children would love,
since she taught natural
resource, would love to
come out on your place
so we arranged it. So it
was just her class, the
following year, we
extended it to another
class until it just kept
growing and growing."
While the field day is full
of fun and games the
children are also actively
learning about the tree
farm and natural
resources. Field day
coordinator Sarah
Fleming from the NRCS
says that's why so many
organizations are eager
to help out.
"It's awesome, very
awesome, I enjoy being
around kids, I enjoy the
school programs. They
enjoyed it, for one
reason they love to be
out of school but I told
them one thing, we're
here to learn and have
fun and they're loving it.
More and more schools
are getting involved in it,
we had one school that
came from out of
Brookhaven this year
and I'm thinking there will
be many, many more."
A constant feature of the
field day throughout the
years has been the date
- it always falls on Bubba
Bass's birthday, and
that's by design. This
event is near and dear to
Bubba's heart. He says
seeing the children have
so much fun on his tree
farm is the best present
he could get.
"That's my birthday
present, we love the kids
and we've watched them
grow up and watched
them come back and it's
great it's just great."
From Monticello,
Mississippi, I'm
Jonathan Parrish
reporting
[BASS FIELD DAY TAG]
THING I LIKED ABOUT
THAT LAST STORY IS
THEY TEACH THE KIDS
THERE SOME REALLY
IMPORTANT THINGS
AND GIVE THEM A
LOVE FOR NATURE.
BUT THEY ALSO GIVE
THEM A CHANCE TO
GET OUTSIDE, GET
SOME EXERCISE AND
GET ACTIVE.
[FOOD FACTOR-GET
ACTIVE INTRO]
---ON CAM---
-------------------------------------------
For more infomation >> Bass Tree Farm Field Day | Farmweek | May 18, 2017 - Duration: 3:09.-------------------------------------------
The Rookie: I'm Ready for Thomas #4 - Duration: 3:45.
Pressure on me.
It really looks simple to me.
You thought you had it already.
It was close, in the beginning.
Hi Lasse.
Hi Thor.
Are you well?
I'm doing good yes, thanks.
And it's going well with the swing?
It's getting better and better.
Fantastic.
My suggestion today is, that instead of practicing the full swing,
there's so many other elements of the game, that we need to work on.
Today we're gonna work on putting.
Have you tried putting before?
Only on the mini golf course.
You're an expert then.
I brought you a putter.
The putter is slightly different to a normal golfclub.
On a normal golfclub, you wanna get the ball in the air, so it's got an angle on.
A putter has hardly got any angle.
So what we're trying to aim for, is to get the club here.
And the shaft to be an extension of your arm.
So you lift the indexfinger on your left hand.
And you place your right hand on the club.
And when you put, the only thing to use, is your shoulders.
When you use your hands, it gets to difficult to controle the distance.
Bend forward.
From your hips.
It has the direction though.
It should actually be easier than mini golf, since you don't have the obstacles.
You wait and see...
If you come over here.
Now you'll put to number five this time.
I have seen on TV, that it looks pretty cool, when they do like this.
And the reason they do that, is to see how much the green slopes.
And...
Maybe a little bit more to the right!
It was close in the beginning.
You thought, you had it already.
I actually thought I was quite good at it.
Oh yeah.
I think I'm ready for Thomas now!
I think you are, and you're in luck.
I brought him along.
Yeah, you brought him today?
Hi I'm Lasse.
I'm Thomas.
So guys, we're gonna do a little challenge.
You put at the same time, and if one of you gets it in, you get one point.
And then you swap over.
Oh, Thomas!
Oh, come on.
Not it should be easy.
I'd say the pressure is on you Thomas, because I don't think I can fail this one.
Show him Thomas.
No way...
Pressure's on me.
I feel a little bit nervous now.
Nooooo!
We have a winner.
Thanks for the game.
Maybe I should wait a couple of weeks, before I meet the real Thomas Bjørn.
Yeah...
-------------------------------------------
BMW X1 2.0I SDRIVE, AUTOMAAT , M SPORT PAKKET,NAVI,XENON,17'' LM VELGEN,CRUISE C,4 ELEK RAMEN - Duration: 1:01.
For more infomation >> BMW X1 2.0I SDRIVE, AUTOMAAT , M SPORT PAKKET,NAVI,XENON,17'' LM VELGEN,CRUISE C,4 ELEK RAMEN - Duration: 1:01. -------------------------------------------
30 LIFE ADVICE TO LULU ON HER 30TH (2 OF 3) | lulusmiles - Duration: 4:23.
For more infomation >> 30 LIFE ADVICE TO LULU ON HER 30TH (2 OF 3) | lulusmiles - Duration: 4:23. -------------------------------------------
Why Faye CAN'T Be An Archer in Fire Emblem Echoes But IS one in Fire Emblem Heroes (Analysis) - Duration: 4:49.
[Faye] There you are, Alm!
[Alm] Hello, Faye. How's it going?
[Faye] I'm doing just fine now.
[Faye] Seeing your face is always a bright spot in my day.
[Alm] Heh. Well, I'm glad it's not a low point.
[Faye] Now, shall I head back out there and slay more of your enemies for you?!
[Alm] Slay...enemies for me? Um...
[Alm] Er, I would hope you're doing it for a better reason than just...me.
[Faye] Oh! Is THAT what you want? ...Because I'll do it.
[Faye] I'll fight for any cause you desire!
[Faye] Just promise you'll be watching, Alm! Promise to look at me!
[Faye] Promise to look at me!
[Alm] Faye, I... Look, just please be careful, all right?
(Swoosh)
(Sword slash)
(Intro Jingle)
What's up guys, Stevie here with Lucky Crit!
I've seen a lot of people in the comments recently wondering why Faye is an Archer in
Fire Emblem Heroes, yet can't be one in Fire Emblem Echoes, so today I thought I'd try
to clear it up a bit and see if I can decode Intelligent Systems' thought process behind this choice.
In Fire Emblem Gaiden, and early Fire Emblem games in general, classes had restrictions
based upon character genders.
In more recent games these restrictions have been relaxed a bit, with characters like Rinkah,
Charlotte, Severa, Selena and many more able to access classes and new versions of classes
that were previously male only, and male characters like Subaki and Shigure who join your army
as Pegasus Knights, (renamed to Sky Knights in Fates) which were previously female only.
Since Echoes is a remake of Fire Emblem Gaiden, and Intelligent Systems has really stayed
true to the source material, it seems that the class restrictions present in Fire Emblem
Gaiden will remain in Echoes.
Villagers are usually able to class change into Mages, Mercenaries, Cavaliers, Soldiers,
and Archers, while Faye, the first female villager in Gaiden and Echoes, will have access
to Cavalier, Pegasus Knight, Mage, and Cleric.
In Gaiden and Echoes, the Archer, Soldier, and Mercenary classes are male only classes,
while as a female, Faye gets access to Pegasus Knight, Cleric, and the female version of
the Mage class, which promotes into a Priestess.
So now why would Intelligent Systems make Faye an Archer in Fire Emblem Heroes if she
can't even be one in Echoes?
I think there are a couple of reasons.
Firstly, since the banner of characters added into the game were from Alm's crew, they wanted
a good variety of male and female characters to bring into Heroes, and didn't want
to do a villagers only banner.
So we got Alm, the sword-wielding main character, Lukas the Soldier, and Clair the Pegasus Knight.
Because they probably wanted some early-game girl characters from Alm's route to add into the game,
their options were limited to Clair, Silque, and Faye.
Since they were adding Clair, they likely didn't want Faye to also be another Pegasus
Knight character, so we can scratch that one off.
As for why they didn't add Silque into the game instead, or why they didn't just add
Faye as a Cleric, since she actually gets access to some interesting spells in that class,
I think they wanted to avoid adding too many healers into the game, and they probably
knew and had it planned out that players would be getting access to Genny in the then upcoming
banner featuring Celica's crew.
Since Celica's banner was also going to feature herself, Boey, and Mae, all as mages, they
probably didn't want to have ANOTHER Mage added into the game in Alm's banner, either.
This leaves Faye as a Cavalier.
So far in the banner we've already got two blue units, and a third just seems overkill.
I suppose she could have been a sword wielding cavalier, but that's also not possible in Echoes,
as Cavaliers in Gaiden could only wield lances.
Furthermore, that makes it a double blue and double red banner, and I think they like to
have more color diversity than that.
So pretty much nothing worked as far as Faye's class options.
There also aren't any axe units in Echoes, so her as a green unit can be crossed off
too, so she was stuck with gray.
Since thieves are also not present as a playable character class or even a remote possibility
in Gaiden and Echoes, it also wouldn't make sense for her to be a thief either.
Which means there were only two options.
Faye the Cleric, or Faye the Archer.
And like I said earlier, I don't think they wanted another Cleric.
(dagger hit)
So if you think about it this way, they didn't have much of a choice if they wanted
the banner to be diverse.
It's still rather unfortunate though, as Faye kinda works as an Archer, and as an Archer
she could definitely snipe Celica and get rid of her so that Alm is all hers...
And that's gonna wrap up today's episode guys, thank you so much for watching.
If you enjoyed this brief look into the world of Fire Emblem trivia, do me a solid and slash
the thumbs up down below, comment "Echoes... or Heroes" in the comment section, and be
sure to voice your concerns or frustrations about Faye there as well if you so desire.
Since Echoes launches in North America TOMORROW, I'd love to hear how hyped you are in the
comment section as well!
Be sure to subscribe for more content like this, and follow us on twitter @luckycritgaming
for behind the scenes info and news revealed on the fly.
And I'll see you all next time!
(Fire Emblem Heroes music)
-------------------------------------------
OU Commencement Weekend | Vlog 22 - Duration: 15:49.
I did not know this was upside down! my bad hahaha
-------------------------------------------
Fidget Spinners GIVEAWAY! (Open) - Duration: 2:03.
Hey everyone its Zeenia from Craftabulous and in todays video I am doing a GIVEAWAY!
So we recently hit 300 subscribers, and thank you guys so much for that!
I actually had a goal of getting to 300 subscribers by the end of May and we reached that goal
before it was even half way through the month so thank you guys so much for that!
So this giveway is to thank you gys for 300 subscribers and just to give back to you guys.
SO now lets just hop right into the part you have been waiting for, the giveaway.
So as you can probably already tell by the title, this giveway is for fidget spinners,
because I know they have been really trendy lately and I thought it would be a perfect
givewaway item.
So I have 2 fidget spinners here so there will be 2 lucky winners to this giveaway so
there is the pink one and the gold one.
So the gold one is metal and the pink one is obviously ceramic.
Both of these spin really well and what I've noticed about these is that the bearings are
like really well attatched so they don't easily come out like some of the other fidget spinners
I have seen.
These are just really nice overall.
So all you need to do to win these fidget spinners is subscribe down below to my channel,
and that is completely free if you didnt already know.
Its just the red button that says subscribe and its just whenever I post a new video,
it will show up in your subscription box.
And then you have to comment down below on any of my videos actually, um you have to
comment which fidget spinner you want so if you want the pink one or the gold one so those
are the only rule.
So good luck on winning these fidget spinners, and make sure to give this video a big thumbs
up if you liked it so I will see you in my next video!
Bye!
-------------------------------------------
Subaru Forester - Duration: 1:01.
For more infomation >> Subaru Forester - Duration: 1:01. -------------------------------------------
Liquid Miracle • Invoker • 7.06 • Meta • — Pro MMR Gameplay Dota 2 - Duration: 39:14.
Liquid Miracle • Invoker • 7.06 • Meta • — Pro MMR Gameplay Dota 2
-------------------------------------------
Contrast Material and Radiation Dose at CT (June 2017) - Duration: 30:51.
[music]
Herbert Y. Kressel, MD Hi. This is Dr. Herb Kressel and welcome to the June Radiology podcast.
Today we have an interesting panel discussion of a pair of articles that we're publishing
in this month's issue that use a physiologically based pharmacokinetic model to look at contrast
dynamics in tissue and the focus of the first paper is to describe the accuracy of the phantom
and the second one looks at the impact of contrast medium on radiation dose in this
model.
I found the papers very interesting.
And we're joined also by the discussant of the articles and an editorial.
So let me introduce everybody.
Dr. Pooyan Sahbaee is a Senior Scientist at Siemens Healthcare and he was a doctoral student
at Duke when this study was written.
Welcome Dr. Sahbaee.
Pooyan Sahbaee, PhD Thanks so much Dr. Kressel.
It's my honor to be here.
Sure and Dr. Ehsan Samei, Professor of Radiology at Duke and a frequent contributor to Radiology.
We're delighted to have you join us as well.
Welcome.
Ehsan Samei, PhD Pleasure to be here.
Yes.
And Dr. Boone, Dr. John Boone, is Professor of Radiology and Vice Chair for Research at
the University of California Davis; and Dr. Boone I have to first thank you for your great
service to Radiology as a reviewer and for the provocative editorial that you have written.
I think it will help our readers place this study in the proper context.
Welcome.
John M. Boone, PhD Good morning.
It's a pleasure to be here.
So let's begin.
Dr. Sahbaee can you tell us about this notion of a physiologically based pharmacokinetic
model that you use to predict contrast dynamics?
Sure.
If that's okay I'll start with a short summary of the objective of the whole study
and then why we needed these physiologically based compartmental models and individual
clinical trials.
Sure.
From a – like if you studied – before we learned that there is a possibility of
increasing radiation dose due to the contrast agent.
We know that everyone is familiar with the phenomena that the presence of contrast agent
in vessels or organs enhances the attenuation and that's why we use the contrast agent.
We know that iodine increases the total radiation dose, meaning that the total radiation to
the tissue mix with iodine.
But the questions were how can we quantify this increase in different organs, and more
importantly like as a function of time and as a function of patients' attributes.
The second question that we really wanted to address was how much of this tissue, how
much of this increase in radiation dose can go beyond the mixture of iodine in the blood
or in other words how much of this increase is biologically relevant.
That was our objective of this study in some area, and we knew that we could only do it
with mutual clinical trial, the reliable mutual clinical trial.
We are aware of the complication of the process and things, but the first part of the study
we developed and incorporated a compartmental model of cardiovascular system which was indeed
a physiological based compartmental model and we in this model we basically modeled
the distribution of contrast agents or the dynamics of contrast agents through the whole
body and it consisted of a series of differential equations which take all the organs and vessel
parameters into consideration and as a result it delivers a contrast material concentration
time(inaudible)to calculate this (inaudible)rate was applied to each compartment and each compartment
was basically consisted of three subcompartments, intracellular, extravascular and intravascular,
three subcompartments.
And then based on as output again we were getting the iodine concentration in different
organs and vessels, but the good feature of this compartmental model was that we could
personalize it based on different patient attributes including like the organ volumes,
including the cardiac output, height, weight, sex, and some other factors we could basically
make them patient specific.
H.Y.K.
So what actual factors were used?
For example, did you include potential variations in renal function, the clearance rates of
the contrast?
In the current model we didn't include the renal function into account, but the other
factors were again like cardiac output, the organ volumes, and we extracted this information
from the real patient models created from the real CT images and all those like organ
volumes, the vascular volumes and all those high space and everything was basically real
lump or real values.
And you had 58 models but how did you choose the distribution of features within those
models?
Were they based on a population or how did you decide how many heavy people and how many
thin people and how many people in failure and whatnot?
This was a population; this wasn't basically first 58 patients created in our lab, in Duke's
lab, which called XCAT phantoms.
These XCAT phantoms were created based on a population of patients which had different
types of patients, body index size like – same number of the like males versus females
and it was like a very well distributed population.
Okay, well good.
How accurate are the models actually?
Dr. Samei?
Dr. Kressel, again great to be with you.
These models as Pooyan already pointed out are based on, most of them are based on whole
body CT scans that we have at our institutions.
We segment these models, we add additional features to the model, we do additional dynamic
components and we try to do a reasonable representation; sampling of the population if you will.
Not as comprehensive perhaps because there are only 58.
These are the first 58 that we have created, but they are representative of low BMI, high
BMI ranges of the patients that we have at our institution.
I think they are reasonably representative of the population at Duke University Health
System with not necessarily, we cannot necessarily say that represented individual patient that
walks into our hospital today.
(inaudible) matching.
So I would say population wise, they are representative, individual wise we are in the process of figuring
out how we can match individual patients to any of these models that we have.
On a population basis we have done a great job that actually has calibrated or validated
that this population contrast enhancement that we see in them are consistent with the
contrast enhancement that we see in a similar population that is reported elsewhere.
How accurate is the model actually?
Population wise it's very close.
I would say in the 5 to 10% range.
(Inaudible)it's difficult to say.
So I was sort of particularly excited with the notion of a virtual clinical trial where
in theory you could introduce a new agent and you could model in some lesions and you
could predict a degree of contrast, so where do we stand with this?
How can you actually use a model like this as a virtual clinical trial?
Yeah so it's a very exciting time actually.
As you know one of the challenges in medicine is that medicine being a scientific enterprise
we hope, you've got to do experiments to be able to validate your hypothesis.
But doing experiments is very difficult in the context of patients.
So virtual clinical trials really addresses that ethical dilemma that we have in that
we want to have evidence validated to experiment, at the same time we can't really do a whole
bunch of experiments that we want to do.
For example, there are a zillion different ways of imaging a patient on MR scanner or
a CT scanner and we cannot possibly entertain that kind of enterprise in the context of
a patient population.
So virtual clinical trials enable us to essentially create a population virtually and experiment
on them without ethical difficulties or pragmatic difficulties informed consenting patients
and variability across the patient.
Also the beauty of this model is that we do know the truth because we created them.
We know what's going on with them.
Now the challenge, the limitation, is that how realistic are these realizations?
If we come up with a contrast distribution or anatomical contrast that is not realistic,
of course we are gonna lead us to the unrepresentative conclusions.
But I think I would say in the last few years we have seen a greater deal of realism in
the formation of these virtual models.
In the latest ones that we are working on we are adding intra-organ heterogeneity that
would even make the images much more realistic looking not just for dose estimation.
I think the great promise of this technology is not just looking at dose.
We just happen to be using this for a dose evaluation, but the idea is that can we actually
bring all elements of the imaging, not only the risk of imaging regardless of how minute
that risk might be, but also the benefit in the construct that we know what the truth
is, and therefore we can have a much more informed way of optimizing the process of
medical care.
So the promise is that we go beyond CT, we definitely want to go beyond dose and risk.
These are just I would say low-hanging fruits if you will.
Dr. Boone are you familiar with these physiologic models?
Where do you think this technology is going to wind up?
I'm certainly familiar with the XCAT models the 58 that has been discussed.
They were sort of developed for Monte Carlo dose estimates.
What I think that the authors at Duke did which is amazing and very exciting and I congratulate
them for doing such an eloquent job with this, is they incorporated this kinetic model with
the vasculature.
Frankly it's something that I've wanted to do and just haven't had the bandwidth
to get around to doing that.
I read a lot of manuscripts from Radiology and other journals and I have to tell you
I think you know when – we just discussed this, I was very excited.
I mean more excited than in several years of reading manuscripts.
So congratulations to the authors for this spectacular work.
And I think where to go from here really is further validation.
You sort of used past data to validate this.
I think it would be fun and exciting to go and probably with a real clinical trial in
a limited number of patients and see if your organ enhancement curves, your time density
curves, really do match.
What can go on in real patients and further validation would give more utility to this
work down the line.
I think that you describe this work as hypothesis generating and I think that's very accurate.
This could be the beginning, the opening salable of a lot of research with the kinetics.
So further validation and that would lead to protocol optimization, maybe a different
timing regime for imaging the kidneys or whatever could change the dose profile and still give
the same physiologic information, things like that.
KB would have an impact here as well.
So it's very exciting and I'm sure that this will have long legs for the people at
Duke and other readers as well.
Yeah I was taken with how it might really affect the introduction of new agents because
you might be able to estimate the effect sizes and then tailor sort of clinical trials to
reduce the numbers because you have a better sense of sort of the magnitude of the effects.
I think it's very, very exciting work.
With that, let's move on to what was your primary goal in this actually which was not
just to validate the model but to look at the impact of the pharmacokinetics of contrasts
on tissue dose.
My question is actually why do this with a model?
I understand that for a lot of the other things, but actually looking at tissue dose, why use
a model as opposed to another experimental method?
That's a very good question.
Of course there are alternative ways of characterizing this phenomenon that we have characterized
here.
You can defer to the physical measurement for example as opposed to Monte Carlo simulations
or human modeling simulations and so on.
There are two reasons for doing it the way we did it.
Number one, is the issue of sampling in that if you even if you have a patient model let's
say an animal model whether a phantom model or a cadaver.
In either of those cases you could put probes inside your unit, whatever that might be,
and make an actual measurement.
The problem is that at best you will get one sample, one realization, two realization.
Doing that across 58 will be overwhelming if not impractical.
So we can't only have one or two conditions evaluated not do it across the population
that we have attempted to do so here.
Number two is that the whole if you're going after contrast agents then the dynamics of
the contrast agent needs to be incorporated.
At different time points, different organs, different tissues, get different amount of
contrasts going in and out of them, so you should do it in sort of a dynamic way across
a wide range of tissue sample.
So if you have it with the animal model, the number of probes that you need to put in and
do the temporal evaluation would be experimentally very, very challenging.
(inaudible) The other thing is you can also now change the cardiac output of your patient
and see what happens.
In the case of animal model you cannot do that as readily.
There's a lot of flexibility and sampling convenience that comes from this kind of model
that otherwise would not be possible.
Got it.
So what did the model show Dr. Sahbaee?
What is the effect on radiation tissue dose from using contrast in different organs?
Sure.
At this point it's important to clarify what we mean by radiation dose.
So the radiation dose we introduced in this study is the total radiation dose delivered
to the iodinated tissue.
Okay so it's tissue plus iodine alright?
But so with this model we showed like the administration of contrast material can increase
the total radiation dose up to like 54% in the kidney.
Okay and also in this study the second question that we wanted to address was we assume that
in highly perfused organs like liver and kidney or maybe lung and brain, the increasing radiation
dose can be approximated by normal distribution or Gaussian distribution reflecting the proximity
of iodine molecules, the organ as it distributes through the blood vessels.
Our results showed that for an individual patient with considering this proximity of
iodine to the organs, the anticipated biological relevant dose increased with respect to the
unenhanced CT can be in the range 0 to 18% increased for liver and same 0 to 27% for
kidney.
I see.
That's pretty substantial.
Now I guess the controversy in this is sort of the whole radiation dose may not be the
biologically relevant dose and there the question is the contrast that's actually intravascular
may not be contributing the same proportion to the tissue dose as the interstitial contrast.
Dr. Boone I know this is something that you've been concerned about, perhaps you could tell
us your thoughts on this issue.
Sure and let me briefly address a question to Dr. Samei, with respect to Monte Carlo
radiation dose assessment versus physical measurements you could only have so many physical
measurements because you use point detectors.
The nice thing about a Monte Carlo program is that every voxel in your phantom becomes
a measurement tool, a measurement probe, so you really have thousands, hundreds of thousands
to millions of individual dose measuring probes in a virtual environment of course.
And as the authors of this great paper recognize as well as many who are involved in Monte
Carlo studies, there are limitations of that and modeling itself has limitations.
The example I gave in the editorial are related to what if a patient has a metal implant.
So obviously most people would recognize that the dose deposited into a titanium or other
metal implant is not biologic in nature and that's a little bit true to iodine flowing
through the vessels temporarily if you – if they absorb some radiation dose they're
going to be urinated out of the body within 30 minutes after the scan.
So that dose may not be as physiologically relevant or contribute to risk as Ehsan was
saying.
The other thing is because most of the contrast agent during a CT scan is imaged early phase
so it's really intravascular, it turns out that the vessels contain of course blood and
blood is plasma and cells and the like and largely there's not a lot of DNA.
There is some, but compared to the tissues in your liver and kidney and brain, there's
really a large void of DNA in the vascular system and DNA is the target for radiation
risks.
The other thing is, is that size matters.
When you're talking about dose supposition you're really talking about, not to get
too technical here, but the x-rays interact with atoms and they kick off electrons and
it's the range of those electrons that sort of determine the resolution requirements of
your phantom and because that range is on the order of 20 to 100 micrometers you would
need a very, very high resolution phantom beyond even modern, impressive computer capabilities
now to fully simulate that.
I'll give you other examples so radiation dose via electrons to blood to feces to urine
in the bladder to implants, none of those really have a biological effect or have the
same biological effect as the regular tissues.
So the tone of my editorial was really that scale matters and we need to get to the point
and this was a great starting discussion for this important issue and then further down
I imagine that we'll refine these models, make them more accurate and get to the bottom
of whether or not this radiation dose really does contribute to risk or not.
So if I may, first of all I think I agree with you for most of the things that you said,
John.
I think we recognize the limitations of our modeling and we have acknowledged that in
the publications.
So none of these are really new to us, I agree.
It would be crazy to compute the dose on implants and say this is the dose of the patient.
Physiologically it's meaningless.
With that being said, these implants, these so-called implants iodinated implants that
we are talking about are much, much smaller admittedly than would be seen in a large metal
implants and they do get mixed in with not only the blood but also in the extra-cellular
blood and extra-cellular space.
So iodine eventually needs to make it from the arteries to the vein.
In order to do so it needs to go to the tissue.
A number of our protocols are essentially orchestrated designed time so that we can
get maximum enhancements for example in kidney or the liver; and during that time in an organ
that is highly vascularized, let's say the liver which is like 60% of – most of the
blood is capillary, you have iodine that is in a very close proximity to the tissue that
has lots of DNA that can be potentially damaged.
We have tried to do a little bit of that modelling in a few, not all of the iodine ends up in
the tissue, there was a secondary analysis that was added to the paper towards the end
assuming some sort of Gaussian distribution but the peak in the tissue would never exceed
51% that goes to the blood at Gaussian distribution.
And even that had a measurable impact on radiation dose that I think that analysis is perhaps
more physiologically relevant which actually we reflect that in the abstract as well.
And actually if I may just interject here as I'm hearing this I'm recalling that
we've published some papers on looking at double strand DNA breaks following CT and
then following CT plus contrast and the - not that double strand breaks are the equivalent
to measuring tissue dose, but the magnitude of the change was sort of more or less in
the same magnitude as I recall, so I guess the issue is it's not hard to understand
that there will be an effect but just sort of how best to express it.
I guess some of the concern is that if you over interpret the data that you'd come
away thinking that there's a lot more effect on tissue dose and I think that the subsequent
experiments that you did I think were very, very helpful at least in scaling the magnitude
of the change.
Right.
That was those papers that you refer to, there was a paper by (inaudible) in Radiology January
of last year and there's a paper that just came out by Leon Wang in European Radiology.
Same strategy, they measured, they used biomarker protein of double strand break, before iodine,
after iodine, before CT, after CT; and their estimation of this biomarker increase following
the administration of contrast and CT was higher than what we estimated which – it's
not what we modeled of course and we were sort baffled almost as to why they estimated
a higher percentage of double strand break than we anticipated.
So in some ways when I read those articles especially Wang's article that just came
out, I mean in some ways I fully relate to what John is objecting because I have the
same objection.
Is some ways you can say we are over estimating.
Yeah.
In fact we said that ourselves in our paper.
We said the range can be between zero to whatever percent you said and you even admit that might
be zero.
But these papers say that it's even more and I feel that it doesn't leave room to
investigate the mechanisms behind this enhanced double strand break.
I also want to add here that, I mean our objective here is really not to discourage the use of
contrast agents or discourage the use of CT in any way; it's just the fact that 60%
of the CT is done with contrast agent and somehow that needs to be incorporated in our
broad scheme of observation.
So Dr. Boone where do we go from here?
How are we going to sort through this?
Well I think that this was an excellent dosimetry exercise.
I think what we need to do is actually recycle some research that was done in the fifties
and sixties on microdosimetry because that will get to the bottom of it and really what
we need to do is better evaluate risks which I think is your ultimate goal here.
So microdosimetry will you probably won't do a whole body, but you could do where the
CT beam is hitting in a phantom and tease out you know the proximity of the iodine atoms
within a large vessel and in a median scale vessel and down to the capillary scale in
all of that.
So lots to do.
We just got five new computers here that are very high tech so we're excited about doing
some follow-up work on this work as well.
Great.
Well this has been a stimulating discussion.
I want to thank you all.
Dr. Sahbaee congratulations on your work and Dr. Samei thanks for sharing your insights
and Dr. Boone thank you again for a fine editorial.
It's been a pleasure speaking with you about this.
Thank you sir.
Thank you.
Bye
Bye-Bye.
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How To Set Up Google Maps Listing 2017 | Google My Business - Duration: 7:13.
Today I'm going to show you guys how to create a google my business listing or google snack
pack listing
Gonna start by going to google dot com
So you input your business name
Now when entering your street address, city, state, zip code and phone number
This has to be the exact information that's on your actual website.
It has to match exactly.
This is very important when setting up your google my business account.
Um
We're going to use a generic address.
For instance if your website address has 18800 Lina street and it's spelled out you want
to spell it out on your google my business listing.
If it's abbreviated you want to abbreviate it.
Same with your phone number, if your phone number has no parenthesis and hyphens you
want have it like that with no parenthesis and hyphens.
If it has parenthesis and hyphens you want to include it when filling this out.
This is also important if your like a mobile business you want to select no.
If you have a brick and mortar location you want to select yes.
So we have all of this filled out
Continue
Googles going
to send you out a post card to verify that, that's your actual location there's going
to be a code inside
When you get your post card comeback to your google my business and enter the code to verify.
Since we're just going this for example purposes we're going to skip that.
So from here you want to complete your profile by adding photos of your business of your
location.
You can ad a virtual tour this supposedly helps increase your rankings when you do a
360 or virtual tour of your business but I haven't tested it tried that out yet.
I'll let you guys know
You want to enter your hours
You can add menus if you're a restaurant
The type of amenities you offer
You want to add as many photos as possible customers like photos and google likes when
you add a lot of photos
By owner Interior
Exterior
Picture of food and drinks if you're a restaurant.
This is where you can add managing members to your business to go in and change things.
If you have multiple locations
You want to have a separate page on your website with the address to that location and again,
the address should match everything that you enter on this form.
That's pretty much it.
It's not really that hard to set up a google my business listing.
The hard part is when your actually trying to rank in the three pack or snack pack.
Which isn't too hard but it's more complicated than this.
I'll do a video soon on how to increase your rankings in the google snack pack
You guys have any questions feel free to leave them in the comments.
If you like this video or if it was helpful or informative please like and subscribe.
Thanks.
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