- So check this out.
You guys are both athletes.
So I read this great article, and it was talking
about how athletes are able to deal with pain
unlike regular people.
Non-athletes cannot deal with pain the way athletes--
So it's real.
Because I was suspecting that was true,
But you're saying that the research verifies that.
Research vers it out.
And so because I know that you're an athlete, I--
- In my day, in my day, - In your day.
Well, yeah.
Well, I'm just going to continue.
Next to me, you are an athlete. - OK.
All right.
All right.
So there's a little thing called the pressure test.
You know what the pressure test is, right?
So you stick your hand in a bucket of ice.
NEIL DEGRASSE TYSON: Yeah.
And most people can only do that for, I don't know,
maybe 30 seconds before the pain that
is associated with the cold causes
you to pull your hand out.
Because you can't find the last Budweiser
at the bottom of the--
[laughter]
CHUCK NICE: Which is how I--
Beer drinkers are good at this, presumably.
CHUCK NICE: That's right.
OK
CHUCK NICE: So I wanted to see if your resistance to pain
was any higher than a regular person's resisting to pain,
and that would be me.
Oh, so what, are you going to punch me in the face?
CHUCK NICE: So I have a bucket of ice.
Come here.
NEIL DEGRASSE TYSON: Oh, you're going to do the ice challenge.
Yes, I have it right here.
Oh!
Oh!
Hey.
Simmer down.
- Oh, you have two, we have two. - Oh!
One for each of us.
Fantastic.
Oh!
OK, I can tell you already I don't want to do this.
[laughter]
All right, let me get a thing out, you know what I mean.
You're going to get an arm out?
So the idea is you stick your hand in the ice,
and the first person who pulls it out
is the person who has the least resistance to pain.
I got a feeling that will be me, because I stub my toe
and I call out of work.
[laughter]
All right.
So we just do this. CHUCK NICE: Yes.
OK.
CHUCK NICE: And we can continue on with this show.
Right, right.
Because I can't wait around for this.
Right. Are you ready?
OK. Let me get mine a little closer.
CHUCK NICE: Yeah, and I'll get mine over here.
All right.
OK, but I got to continue to show.
OK. We can continue the show.
NEIL DEGRASSE TYSON: OK. Ready?
Ready?
NEIL DEGRASSE TYSON: OK.
Three, two, one, go.
So here's something interesting.
Athletes--
I have to pee.
--they sit in ice baths.
They sit in ice baths to-- you know, pitchers.
You were a pitcher in baseball.
Didn't you ice down your shoulder?
SPEAKER: Yes.
NEIL DEGRASSE TYSON: Yeah, OK.
[laughter]
(LAUGHING) Chuck, what's the matter?
What's the matter, Chuck?
[laughter]
This is [bleep].
[laughter]
So is this mental toughness here?
All right, that's it.
Oh my god.
NEIL DEGRASSE TYSON: What is going on here?
Is it mental toughness?
[applause]
No, no.
Just to be clear, it's not that this doesn't hurt me.
It's just that I'm OK with it.
You are a dominatrix best dream.
[laughter]
NEIL DEGRASSE TYSON: OK.
[applause]
For more infomation >> An Icy Challenge, Accepted | StarTalk - Duration: 3:15.-------------------------------------------
Are Referendums Bad For Democracy? - Duration: 4:25.
2016 was the year of controversial referendums.
In Colombia, voters rejected a peace deal that would have brought an end to half a century
of war.
In the United Kingdom, voters opted to leave the European Union, the first country to do
so since the Union's formation.
And in Thailand, voters gave the military greater control over the country, alienating
the democratic process.
Most passed by relatively narrow margins, and shook establishment ideals to their core.
So what are the inherent dangers in holding referendums?
Well, some believe that referendums are undemocratic, despite serving as a direct form of democracy.
In fact, referendums ultimately serve to highlight the flaws in having policy decisions made
by majority rule.
Referendums are nothing new, they've been used since Ancient Rome to decide issues of
policy.
Even Adolph Hitler was able to consolidate power by way of a referendum.
But today, most democratic countries operate as "representative democracies", meaning
that instead of citizens voting directly on policy issues, as they do during referendums,
they instead vote for elected officials.
These officials are implicitly trusted to learning about the ins-and-outs of policy,
and what potential pitfalls or benefits each decision may have.
But with referendums, voters are tasked with these nuanced decisions, something many do
not have the time or inclination to fully understand.
Most voters must rely on news, social media, their friends and family, and other non-direct
or fully informed sources.
In some cases, this has led to voters being mislead, such as with a Brexit campaign in
the UK, promising to redirect 350 million pounds a week from payments to the EU, to
the country's overburdened healthcare system.
Some voters cited this as a convincing argument to leave the EU.
But following the vote, its lead proponent backtracked on the statement, saying it was
a "mistake", and that the money would not necessarily go to healthcare.
Another major problem is that the substance of a referendum can end up being ignored,
in favor of whichever political party supports it.
In Italy, for example, a referendum on clearing up a time-consuming bureaucracy ultimately
ended up being treated, by many, as a referendum on the popularity of the prime minister.
Because the PM promised to resign if the referendum was not passed, it gave voters an entirely
unrelated reason to vote, without even considering the question on which they were voting, skewing
the results.
Finally, and perhaps most problematically, this form of direct democracy highlights the
entire purpose of representative democracy: protecting minority rights.
Implicitly, the majority will always overrule a minority, a situation called "tyranny
of the majority".
For example, for hundreds of year in the United States, African Americans were denied the
right to vote, meaning they were denied the right to democracy, simply because the majority
was white.
In fact, many who opposed giving African Americans this right to vote did so as to protect their
majority interests, and ultimately it took a constitutional amendment to fix this injustice.
Referendums open the door to this sort of anti-democracy ideal, and allow an almost
equal half of the voting population to exert overwhelming control on the other half.
2017 will likely see two major referendums, one on the independence of Catalonia from
Spain, the other, in Turkey, would grant the president more power.
But the reasons listed, and others, suggest referendums are inefficient methods of effecting
change in government.
On the other hand, some people support the idea of referendums as they can give the voice
of the country back to its people, rather than vesting it in political officials.
Direct democracy via referendum does work on a local level, and Switzerland, for example
has held more than 600 referendums in its political history.
But whether you think these votes help or harm a country, there is no question that
referendums are incredibly powerful tools of change.
So, what about the United States?
Can it truly be called a democracy, or is it something else entirely?
Find out in this video.
In a representative democracy, citizens vote for elected officials who collectively vote
in the place of citizens and are expected to represent their best interests.
Although that's a step above having a monarchy or oligarchy you didn't vote for, it isn't
a direct democracy.
Thanks for watching Seeker Daily, please don't forget to like and subscribe for more videos
every day.
-------------------------------------------
(SFM Ponies) Frieza Meets Super Kami Guru (Side-by-side comparison) - Duration: 2:45.
For more infomation >> (SFM Ponies) Frieza Meets Super Kami Guru (Side-by-side comparison) - Duration: 2:45. -------------------------------------------
Приколы с рэперами:JAY-Z, SNOOP DOGG, COOLIO, WIZ KHALIFA, RICK ROSS, 50 CENT #RapNews USA: Spin-Off - Duration: 5:22.
For more infomation >> Приколы с рэперами:JAY-Z, SNOOP DOGG, COOLIO, WIZ KHALIFA, RICK ROSS, 50 CENT #RapNews USA: Spin-Off - Duration: 5:22. -------------------------------------------
American Housewife 1x10 Promo "Playdate" (HD) - Duration: 0:16.
American Housewife 1x10 Promo Season 1 Episode 10 Promo
-------------------------------------------
Explore for Kids with Steve and Maggie | English Stories and Songs for Children - Duration: 3:27.
For more infomation >> Explore for Kids with Steve and Maggie | English Stories and Songs for Children - Duration: 3:27. -------------------------------------------
БОЛЬШАЯ СТРАЙКБОЛЬНАЯ РАСПАКОВКА. ИТОГИ 2016. МАСШТАБНЫЕ ПЛАНЫ НА 2017 - Duration: 9:51.
Hello, I'm Marty. I would like to answer your questions, but there were too many. I decided to answer later
In this video I'll do a great airsoft unboxing, sum up the year, tell your goals for 2017
If you subscribe to my instagram, you know that in this box. If not, be sure to sign up, link in description
The first box is not an airsoft stuff
Silver button Youtube. Its yield when the channel 100,000 subscribers
This is the number of subscribers, I received more than a year ago, and the button went before me all the time
Ironically, Russia Mail is not to blame
10 months from the United States to my office in Moscow and another 2 months - to me
Now look what the gun was sent to me by my sponsors. Reviews of them will see in the next year
New AKS74 by G&G
Pretty Heavy. Review in January 2017
Open the large box
A lot of guns in it
Now I sum up. I started to develop my channel 4 years ago. Each year, subscribers gain increased
12,000, 50,000, 140,000, now I have 230,000 subscribers
I did not plan it, but we did it. It is very much for the Russian-language channel of the airsoft
I did not plan this amount in 2016. But I have a goal at the end of 2017 - 500,000 subscribers
That's my main goal. My strategy was effective, I did a lot of airsoft gameplay in 2016
I attracted a lot of foreign spectators thanks English subtitles
I plan to do a lot of sniper gameplay and use other guns
There will also be reviews, unboxing, Tutorials
The main course content will be gameplay, because these videos attract more views and subscribers, including foreign
I want to my channel became the most popular non-English speaking world airsoft channel
Who is the world's first channel is a French airsofter, but I plan to overtake it in 2017
But for this I need your help
Further information is for Russian viewers. Thanks for watching, Like, subscription, happy new year
-------------------------------------------
News Alert . Trump latest News Today 12/29/16 - USA morning news - Duration: 36:05.
For more infomation >> News Alert . Trump latest News Today 12/29/16 - USA morning news - Duration: 36:05. -------------------------------------------
Baby Wildebeest Meets Baby Hyena | Destination WILD - Duration: 2:51.
NARRATOR: Another week, another milestone.
Neo is old enough to join the other calves
in the creche, a nursery which loosely forms
in the center of the herd.
Mom's grateful for the extra freedom.
Relieved of babysitting duty, she
grazes a little distance away.
But no one notices when Neo bounces right out of the circle
on his own mission.
The other youngsters play together in the creche,
unaware of Neo's absence.
Neo doesn't recognize those strange looking ears.
Short grass hides a lot if you're not tall.
The hyena junior is a baby himself,
equally curious about the strange smell
and shape coming closer.
They have no knowledge of each other
so there's no aggression or fear.
Their relationship as predator and prey
hasn't been defined yet.
It's just another game until mother hyena arrives.
Neo remembers his lesson.
Run.
A week old calf can easily outrun a hyena.
Junior loses a playmate, but Neo learns to identify
another predator enemy.
Mom comes the moment she hears Neo call.
But the danger has passed and for the first time,
he didn't need mom to rescue him.
-------------------------------------------
Weekly Wire Rundown: Dec. 29, 2016 - Duration: 3:26.
WELCOME TO A NEW WEEK ON THE RUNDOWN.
ON THIS EPISODE, CHANGES TO SELECTIVE REENLISTMENT BONUSES, NAVY COOL HAS SIX THINGS YOU NEED
TO KNOW, AND WE WELCOME BACK RATING TITLES.
THE NAVY RELEASED CHANGES TO THE S-R-B AWARD PLAN FOR ACTIVE DUTY AND FULL TIME SUPPORT
SAILORS.
THE CHANGES INCLUDE 26 S-R-B AWARD LEVEL INCREASES AND 49 AWARD DECREASES.
IT ALSO ADDS 49 NEW SKILLS WHILE REMOVING SEVEN SKILLS ABLE TO RECEIVE BONUSES.
AWARD LEVELS ARE ADJUSTED BASED ON RATING REQUIREMENTS AND NEEDS OF THE NAVY.
SKILL REMOVALS AND AWARD DECREASES WILL NOT GO INTO EFFECT UNTIL 30 DAYS AFTER THE RELEASE
OF THE NAVADMIN.
READ ABOUT THE CHANGES FOR SPECIFIC RATINGS IN NAVADMIN 284/16 ON N-P-C AND READ OUR STORY
ON NAVY.MIL FOR MORE DETAILS.
THE CENTER FOR INFORMATION WARFARE TRAINING HAS RELEASED SIX THINGS SAILORS NEED TO KNOW
ABOUT NAVY COOL.
NAVY COOL PROVIDES CREDENTIALING OPPORTUNITIES FOR SAILORS THROUGH TRAINING, EDUCATION AND
EXPERIENCES RELATED TO CIVILIAN OCCUPATIONS.
NAVY COOL OFFERS OVER 18 HUNDRED FUNDED CREDENTIAL OPPORTUNITIES FOR ENLISTED PERSONNEL.
THESE CREDENTIALS CAN HELP SAILORS DURING AND AFTER SERVICE IN THE NAVY MAP AND DEMONSTRATE
THEIR TRAINING AND SKILLS.
NAVY COOL ALSO PROVIDES FUNDING FOR EXAMS AND CERTIFICATION FEES.
THAT MEANS YOU DON'T PAY FOR CREDENTIALING.
THERE ARE ALSO MORE THE 15 HUNDRED CREDENTIALING OPPORTUNITIES FOR OFFICERS.
YOU CAN ALSO VIEW AND PRINT ADVANCEMENT EXAM BIBS ON NAVY COOL FOR SAILORS PREPARING FOR
THE NEXT ADVANCEMENT EXAM.
CHECK OUT THE NAVY COOL WEBSITE BY VISITING COOL DOT NAVY DOT MIL.
ALSO READ THE STORY ON NAVY DOT MIL FOR MORE ON THE SIX THINGS YOU NEED TO KNOW.
LASTLY, YOU CAN ONCE AGAIN REFER TO ME AS MC2.
NAVY LEADERS HAVE REVERSED THE DECISION TO DO AWAY WITH RATING TITLES EFFECTIVE IMMEDIATELY.
THE CHANGE WAS MADE BASED ON FEEDBACK FROM SAILORS AND TO AVOID UNNECESSARY DISTRACTIONS
FROM THE NAVY'S GOALS.
CNO AND MCPON SPOKE ON THE CHANGE DURING AN ALL HANDS AT THE PENTAGON.
HERE'S A CLIP.
((CNO) ABOUT
20 MINUTES AGO WE RELEASED A NAVADMIN
MESSAGE THAT RESTORES RATING TITLES AND
TO GIVE YOU A LITTLE BIT MORE
MORE INFORMATION ON THAT I'LL ASK THE MCPON TO TELL
YOU ALL WHAT THAT WAS ALL ABOUT, WHAT IT
MEANS, AND WHAT ARE OUR WAYS GOING FORWARD.
((MCPON)) WE REALIZED THAT THE
MAJORITY OF OUR TIME HAS BEEN SPENT
CENTERED ON CONVERSATIONS SOLELY BASED
ON A NAMING CONVENTION, WHICH WE BELIEVE IS PROBABLY
BECOME A DISTRACTION AND TAKEN AWAY FROM
THE THINGS THAT EACH AND EVERY ONE OF US
SHOULD BE FOCUSED ON EVERY DAY: OUR
MISSIONS, OPERATIONS, AND OUR WAR FIGHTING
EFFORTS OUT THERE, BUT KEEP IN MIND THIS
DOESN'T TAKE AWAY FROM THE LARGER EFFORT
THAT WE'RE TRYING TO DO IN THIS RATING
MODERNIZATION AS WE CONTINUE TO THINK
ABOUT THOSE THINGS THAT WE'VE DISCUSSED
SINCE THE ANNOUNCEMENT OF RATING
MODERNIZATION, WHICH IS CAREER
FLEXIBILITY.
((MC2) WATCH THE ENTIRE VIDEO BY VISITING THE NAVY'S
YOUTUBE CHANNEL.
ALSO READ THE STORY ON NAVY.MIL FOR MORE FROM THE NAVY'S LEADERSHIP ON THE CHANGE.
THAT'S ALL FOR THIS WEEK; FOR ANY QUESTIONS, SEND US A MESSAGE AT USNPEOPLE.FCT@NAVY.MIL.
FOR THE CHIEF OF NAVAL PERSONNEL, I'M MC2 LJ BURLESON.
THANKS FOR WATCHING.
-------------------------------------------
"Die 2016" donuts flying off Rebel Donut shelves - Duration: 0:43.
CHARGING STATIONS.
20-16 HAS BEEN A ROUGH
YEAR FOR A LOT OF
PEOPLE... AND
THIS MORNING REBEL DONUT
IS ENCOURAGING YOU... TO
EAT YOUR FEELINGS.
OWNER CARRIE METTLING
DECIDED TO PUT HOW SHE
FEELS ABOUT THE YEAR ...
ON A DONUT. SHE POSTED
THE NOT-SO SWEET
MESSAGE "DIE 2016" ON
FACEBOOK AND IT TOOK
OFF...
EVERYONE WANTED ONE. SO
SHE DECIDED TO MAKE THEM
TO
SELL, SO EVERYONE CAN
ENJOY THE SWEET SENDOFF
TO 2016.
lets have a better 2017
so i don't have to post
satire on donuts i dont
know hahaha
SHE SAYS YOU BETTER GRAB
ONE BEFORE THE NEW
YEAR... THEY ARE
FLYING OFF THE SHELVES.
-------------------------------------------
2016: A Year in Space - Duration: 0:46.
[TEXT: 2016 A Year in Space]
[March 1: Astronaut Scott Kelly pushes the boundaries of long-duration spaceflight]
[and sets the American record for time spent in space.]
[April 8: After delivering cargo to the ISS,]
[a SpaceX Falcon 9 returns by landing on a floating droneship.]
[August 24: Astronomers discover Proxima b,]
[a potentially habitable planet at our neighboring star system.]
[August 29: Kate Rubins sequences DNA in space,]
[creating new opportunities for identifying life forms beyond Earth.]
[December 4: NASA's Cassini spacecraft plunges into Saturn's rings,]
[giving us a never-before-seen view of the planet.]
[December 25: Premiere of "Hidden Figures," the story of three African-American female mathematicians]
[instrumental in several of NASA's greatest achievements]
[For more videos, go to share.america.gov]
[Photos & Video Courtesy NASA/20th Century Fox/SpaceX/ESO]
[Produced by the U.S. Department of State]
-------------------------------------------
Présentation du Trofinetide par Neuren Pharmaceuticals (sous-titres FR) - Duration: 10:09.
Introduction to Neuren.
Neuren Pharmaceuticals is a biopharmaceutical
company, developing new medicines for
diseases and disorders of the central
nervous system or "CNS".
We have four ongoing clinical development programs
on acute conditions : traumatic brain injury
and concussion, and chronic disorders :
Rett syndrome and Fragile X syndrome,
as well as preclinical R&D programs
in a range of other CNS conditions.
Our expert team in Australia,
the US and the UK, includes people with
many years of experience in all aspects of
pharmaceutical development and commercialization.
Neuren shares are traded on the Australian Securities Exchange,
under the code NEU.
What is Trofinetide ?
Trofinetide is the name proposed by the
World Health Organization for our lead
clinical-stage drug candidate.
It is an analog of a molecule, which is derived
from IGF-1 and occurs naturally in the brain.
IGF-1 is a growth factor
stimulated by growth hormone.
In the central nervous system, IGF-1 is produced
by both of the major types of brain
cells : neurons and glia.
IGF-1 in the brain is critical, both
for neural development and for responding
to injury and disease.
In the brain, IGF-1 gets broken down in two separate
molecules : one often referred to as
glypromate - or GPE - comprises the last
three peptides of IGF-1.
GPE affects glial cells, astrocytes and microglia,
while IGF-1 itself mostly affects neurons.
One of the effects of GPE is that
it actually increases production of IGF-1
by neurons and glial cells.
Trofinetide is Neuren's chemically modified
form of GPE, that can mimic GPE's natural
function in the brain.
The small modification results in the drug having
an increased half-life in the circulation,
better stability for easier storage and shipping,
and suitability for use as an oral medication,
whereas GPE itself and
IGF-1 can only be administered by injection.
In the brain, the role of IGF-1 and GPE
is to facilitate the brain's development
and maintain the biological balance
required for normal functioning.
These processes have evolved over millions of years
and are still being extensively
researched by scientists.
During development, the brain and the cells that
make it up change rapidly and in complex ways.
IGF-1 and GPE play a significant
role in regulating these changes.
In the mature brain, IGF-1 and GPE play
an equally important role in responding
to disease, stress and injury.
Whereas most drugs typically exert a
specific effect on a specific target,
Trofinetide exerts diverse effects which
can help to control or normalize
abnormal biological processes in the brain.
Common Pathology Among CNS Disorders
All the different CNS conditions, brain injury,
neurodevelopmental disorders and
neurodegenerative diseases can result in
very different symptoms and outcomes,
many share common underlying
pathological features.
These include : inflammation, overactivation of microglia
(a type of glial cell),
dysfunction of synapses
(the connections between neurons
through which information is transmitted)
and reduced levels of IGF-1.
In other words, diseases and conditions caused by
different mechanisms often result in the
same pathology, at the cellular and
molecular level.
Let's look at these four features.
Inflammation.
Inflammation in the brain,
often referred to as neuroinflammation,
is perhaps the most common pathological
feature of CNS disorders.
Much of it is the result of excess production of
molecules called inflammatory cytokines.
These are prominent in brain injuries,
neurodevelopmental disorders such as
Rett and Fragile X syndromes, as well as
autism, neurodegenerative diseases like
Alzheimer's and Parkinson's and even
so-called normal aging.
Neuroinflammation places significant stress on brain cells.
Stress can disrupt normal cellular processes,
such as information signaling,
increase energy requirements beyond the
ability of the cells to meet their
metabolic needs,
disturb electrical functions which can lead to seizures
and other abnormalities, and even result in
premature cell death.
In animal models, ranging from brain injury and stroke
to Fragile X syndrome to age-associated
cognitive impairment, Trotinetide has
showed an ability to significantly reduce
the levels of inflammatory cytokines.
This has resulted in an improvement in a wide
range of symptoms including
post-traumatic seizures, anxiety,
memory impairment and hyperactivity.
Microglial activation.
Microglia are the resident immune cells in the brain.
Once thought to serve primarily a
sentinel function, responding to
infection and damaged cells by
surrounding and removing them from the
CNS, it is now known that they play a
central role in maintaining synapses
during development and in mature brains
by pruning dendrites (the many small
extensions of neurons that form synapses).
Microglia are also a key source of IGF-1.
Due to this wide-ranging maintenance function,
they have appropriately been
referred to as the "constant gardeners" of
the brain.
Microglia are not only activated in response to
infection and injury.
They are also activated by
inflammation that accompanies acute
brain injury and chronic CNS conditions.
In this activated state, they not only
lose their ability to effectively
perform their normal function in
synaptic maintenance, but also produce
more inflammatory cytokines which can
further compound and damage neurons
and other brain cells.
Trofinetide has been shown to normalize microglial biology
and function, in both acute and chronic conditions.
Restoring normal microglial activity has resulted in
improved synaptic structure as well as correction
of imbalance and synaptic signaling and
cell-to-cell communication.
This has led to reversal of symptoms such as
impaired memory, anxiety, hyperactivity and
compromised social behavior.
Synaptic dysfunction.
Neurons communicate with each other by chemical and
electrical signals transmitted via synapses.
Normal synaptic function is essential for healthy brain function
and underlies memory, cognition, behavior
and other brain activities.
Normal synaptic function requires that
the dendrites (part of the neurons which
form synapses) are appropriately formed
as well as that excitatory and
inhibitory signals are kept in balance.
When dendritic structure and synaptic
signaling are abnormal, virtually all
brain activities can be negatively impacted.
Synaptic dysfunction is then
identified as a core feature of many CNS conditions,
including acute brain injury,
neurodevelopmental disorders and
neurodegenerative diseases.
For example, in Rett syndrome,
dendrites are sparse and immature,
while in Fragile X syndrome,
dendritic branching is excessive
although the dendrites are also immature.
Trofinetide increases the length
and branching of dendrites
in the model of Rett syndrome
while increasing pruning of
excess branching in Fragile X syndrome.
In the Fragile X animal model, aberrant
synaptic signaling was normalized within
15 minutes of the first dose.
IGF-1 dysregulation.
As previously mentioned,
IGF-1 levels in the brain have been
reported to be depressed in a number of
CNS conditions, particularly in Rett and
Fragile X syndromes and brain injury.
In these conditions, the critical role of
IGF-1 and GPE in maintaining and
repairing brain cells and synapses is impaired.
In the Fragile X model, in which
the IGF-1 level is depressed,
Trofinetide increases the amount of IGF-1 to
normal levels.
This was accompanied by normalized synaptic signaling
and complete reversal of cognitive and
behavior abnormalities.
In the model of Rett syndrome,
increasing IGF 1-levels has been
reported to correct deficits in dendritic spines,
and in isolated cells
from human Rett syndrome patients, both
IGF-1 and GPE are able to partially
reverse the deficits in cellular function.
Summarizing, Trofinetide helps to
correct four of the hallmark pathological
features of many CNS disorders :
inflammation, abnormal microglial function,
impared synaptic signaling and
disrupted IGF-1 expression.
By simultaneously targeting multiple
processes, Trofinetide works to restore
the natural balance of brain function.
For more information, please visit our website.
-------------------------------------------
Temps dip back into the 40s Thursday - Duration: 1:46.
ATURES WARMING UP INTO THE
40s ABOVE AVERAGE THIS TIME OF
YEAR.
BUT AGAIN, TODAY WILL BE WINDY.
AVERAGE HIGH IS 38 DEGREES.
BUT BY 4:00 P.M. WE WILL BE
REACHING OUR HIGH OF 45.
NOW YESTERDAY OUR HIGH WAS 53.
SO WE WON'T BE QUITE AS WARM AS
YESTERDAY.
YOU STILL WILL WANT THE COAT IF
YOU ARE HEADING OUTDOORS OR IF
THE KIDS ARE HEADING OFF TO THE
ICE RELATIONSHIPING OR WHEREVER
THE WHEREABOUTS WILL TAKE THEM.
YOU WILL WANT THE WINTER LAYERS.
BY 6:00 P.M. CLEAR SKIES.
TEMPERATURE OF 39 DEGREES.
WINDS GUSTING UP TO 30 MILES PER
HOUR.
HIGHS ACROSS THE REGION TODAY,
42 IN CHILLICOTHE.
47 FOR LAWRENCE, KANSAS.
45 IN KANSAS CITY.
ENJOY THE 40s.
TOMORROW WE WILL BE BACK INTO
THE 50s.
BUT LET'S TALK ABOUT SATURDAY.
NEW YEAR'S EVE PLANS.
6:00 P.M. MOSTLY CLEAR SKIES.
TEMPERATURE OF 36 DEGREES.
BY 9:00 P.M. HAVE A JACKET ON.
TEMPERATURES WILL BE FALLING 31
BY 9:00 P.M. AND AT MIDNIGHT AS
WE RING IN THE HAPPY NEW YEAR
TEMPERATURES OF 27 DEGREES AS WE
GREET THE YEAR OF 2017.
NOW, AS WE START OFF THE YEAR OF
2017, COLD ARCTIC AIR IS BACK
INTO OUR FORECAST SO THIS IS
WHAT WE ARE WATCHING FOR NEXT
WEEK.
WE HAVE A STORM SYSTEM THAT WILL
MOVE ACROSS THE MIDWEST
IMPACTING US ON MONDAY AND
TUESDAY WITH POSSIBLE
PRECIPITATION BUT AFTERWARDS THE
COLD AIR IS GOING TO BE PUNCHING
BACK INTO OUR SEVEN-DAY
FORECAST.
SO LET'S GO AHEAD AND TAKE A
LOOK AT IT.
SUNNY SKIES THE NEXT COUPLE
DAYS.
FRIDAY A HIGH OF 51.
ENJOY IT.
SATURDAY, SUNDAY, NEW YEAR'S
EVE, NEW YEAR'S DAY.
HIGHS IN THE LOW 40s.
STAYING DRY.
AND MONDAY WE HAVE A CHANCE OF A
RAIN SNOW MIX.
-------------------------------------------
Ridgeland bank robbed - Duration: 0:54.
Keegan: JACKSON POLICE REESEED
THIS PHOTO OF A SUSPECT THEY ARE
LOOKING FOR.
SOMEONE ROBBED TRUSTMARK BANK ON
COUNTY LINE ROAD IN RIDGELAND
SHORTLY AFTER THREE THIS
AFTERNOON.
POLICE SAY MAN HANDED A TELLER
AN ENVELOPE AND A CLOTH BAG.
THE ENVELOPE CONTAINED A NOTE
THE BAG WITH MONEY FROM HER
DRAWER.
WE SPOKE TO A CUSTOMER WHO
SHOWED UP, RIGHT AFTER THE THIEF
LEFT WITH THE CASH.
>> THE ORANGE STRIPS WERE ALL
WRAPPED AROUND AND EVERYTHING
AND I SAID SIR, I AM TRYING TO
GET SOME MONEY.
HE SAID MA'AM, WE HAVE JUST BEEN
ROBBED.
I SAID IS ANYBODY HURT.
HE SAID NO, MA'AM, NOBODY HAS
BEEN HURT.
Keegan: THE SUSPECT IS DESCRIBED
AS A SLENDER MAN, WEARING A
BLACK JACKET, BLUE JEANS AND RED
AND BLACK HAT.
POLICE SAY NO WEAPON WAS
-------------------------------------------
Passengers stranded overnight after Allegiant cancels flights - Duration: 1:43.
AURANT.
JAZMIN: THIS MORNING ALLEGIANCE
AIRLINES IS WORKING OVERTIME TO
RESOLVE SOME HOLIDAY TRAVEL
TROUBLE.
SOME PASSENGERS ENDED UP
STRANDED IN SANFORD.
HADAS BROWN IS LIVE IN THAT AREA
THIS MORNING.
DO YOU HAVE ANY UPDATES?
HADAS: THEY ARE JUST HOPING TO
BOARD THOSE NEW FLIGHTS AND GET
HOME.
SOME OF THEM TRIED TO CHECK IN
EARLIER BUT THEY WERE TOLD THEY
WOULD NEED TO COME BACK, THAT IT
WAS TOO EARLY AND THERE WERE
OTHER CUSTOMERS WITH EARLIER
FLIGHTS.
THERE WERE 12 FLIGHTS IN AND OUT
YESTERDAY AND SEVERAL WERE NOT
RESCHEDULED.
10 OTHER FLIGHTS WERE DIVERGED
TO OTHER AREAS.
ALL OF THIS HAPPENING ON THE
BUSIEST TRAVEL DAY OF THE YEAR.
ALLEGIANT ISSUED VOUCHERS TO
CUSTOMERS BUT WITH ALL OF THOSE
CANCELLATIONS THERE WERE NOT
MANY ROOMS LEFT.
FIVE PASSENGERS WERE LEFT
STRANDED AND SPENT THE NIGHT IN
THE AIRPORT.
>> IT GOT PRETTY BLEAK AND IT
WAS COLD AND THERE WERE FIVE OF
US HERE.
WE LOOK OUT FOR EACH OTHER.
BUT OTHER THAN THAT IT IS
EXTREMELY QUIET.
>> ALLEGIANCE SAID IN A
STATEMENT THE UNEXPECTED WEATHER
WAS AT FAULT AND IT HAD A SEVERE
IMPACT ON THE AIRLINES
OPERATIONS.
THE AIRLINE SAID IT SINCERELY
APOLOGIZES TO CUSTOMERS FOR
DISRUPTIONS TO THEIR PLANS.
THOSE CUSTOMERS THAT HAD TO
SLEEP IN THE AIRPORT OVERNIGHT
AND TURNED AWAY FROM CHECK IN
OUR BACK RIGHT NOW.
LET'S HOPE THEY CAN CHECK IN AND
GET HOME.
-------------------------------------------
CHRISTMAS EVE & DAY IN MADRID SPAIN VLOG 003 - Duration: 4:37.
Santa gave me a Star Wars lego at my place
and in my grandma's Lego Dimensions
A videogame and a Lego
At grandma's place a power ranger gun.....
And Magic Sand at my place
A Nintendo, a videogame, a PJ and also.....
a Star Wars costume
A Washi tape and a Sylvanian Family with their babies
-------------------------------------------
VIDEO: Tax season is almost here - Duration: 0:42.
PSASHA: MANY OF US ARE TRYING TO
PPLAN HOW WE WANT TO SPEND NE
PYEAR'S EVE.
PBUT BEFORE 2017 COMES, THERE ARE
P-- NOW IS THE TIME TO GET AHEAD
PON TAXES.
PBANKRATE.COM REPORTS IF YOU
DONATED TO A CHARITY, YOU CAN BE
PREWARDED DURING TAX TIME.
PYOU'LL EITHER NEED A NOTE OR
PSOME FORM OF DOCUMENTATION FROM
PTHE GROUP.
PIF YOU DONATED CLOTHING OR
PHOUSEHOLD ITEMS, GET A RECEIPT
PFOR THOS
PYOU CAN ALSO GET A TAX BREAK FOR
PVOLUNTEERING.
PACCORDING TO THE WEBSITE, YO
PCAN DEDUCT 14 CENTS FOR EACH
PMILE YOU DROVE TO VOLUNTEER.
PBY GETTING YOUR TAXES IN ORDER
PEARLY, THIS GIVES YOURSELF
PPLENTY OF TIME TO FILE THEM
PCORRECTLY AND EVEN SAVE YOU SOME
PMONEY.
-------------------------------------------
Surprise For Boy With Heart Condition - Duration: 0:53.
ITH SPENT 13 OF HIS 16 SEASONS
AS A PANTHER.
HE PLAYED IN THE PANTHER'S FIRST
SUPER BOWL APPEARANCE BACK IN
2004.
THE 37-YEAR-OLD SAYS EVEN THOUGH
HE COULD CONTINUE TO PERFORM
WELL ON THE FIELD, IT'S TIME TO
HANG UP THE CLEATS.
BETHANY: PANTHERS QUARTERBACK
CAM NEWTON JUST GAVE AN
INCREDIBLE GIFT TO A LITTLE BOY
BATTLING A SEVERE HEART
CONDITION.
>> HOW ARE YOU DOING?
YOU DOING GOOD?
BETHANY: ALL HE HAD TO DO WAS
SHOW UP.
NEWTON FLEW TO ATLANTA WHEN HE
HEARD ABOUT 10-YEAR-OLD TAYLOR
DECKARD.
HE'S ALWAYS WANTED TO MEET THE
FOOTBALL STAR SO THIS WAS A
WELCOME SURPRISE.
NEWTON IS KNOWN FOR HIS
CHARITABLE WORK WITH THE CAM
NEWTON FOUNDATION.
BRIANA: YOU HAVE TO ADMIT THAT'S
PRETTY COOL.
BETHANY: YOU SEE HIM DO STUFF
LIKE THIS A LOT.
-------------------------------------------
Compare Loom & Leaf
For more infomation >> Compare Loom & Leaf-------------------------------------------
CookieSwirlC MagicMeeMee... For more infomation >> CookieSwirlC MagicMeeMee...-------------------------------------------
Cleveland Browns Cheerleader | Hardest Jobs in Sports - Duration: 2:05.
- Being an NFL cheerleader is all about bringing pep,
supporting the team,
creating joy and celebrating the team's successes.
But I cheer for the Cleveland Browns.
(sad music)
Finding something to cheer for with the Browns is hard.
Fumbles, sacks, injuries,
fumble-sack-injury safeties,
Browns football isn't very cheery.
Any NFL cheerleading is hard.
There are all these rules.
You're not allowed to gain weight, or date a player,
or put your head in your hands and cry.
That one's specific to Cleveland.
The stadium is kind of a feedback loop of sad.
The coaches are sad, which makes the players sad,
which makes the fans sad, which makes the coaches sad,
which makes the players sad, which makes the fans sad.
It's... just a lot of sad.
It's gotten to the point
where sometimes we ditch practice to brainstorm new cheers.
- [Cheerleaders] Less! (clapping)
Less! (clapping)
Turn the ball over a little bit less!
(cheerleaders sighing)
- We made a swimsuit calendar for the fans,
but it was after we blew a twenty point lead to the Ravens.
It's not really selling.
(crying) I'm trying my best.
It's not my fault the Browns
let two good free agent offensive linemen walk.
I always try to keep things positive,
like, all the Browns are in the NFL,
so, that means
they're some of the best football players in the world!
And that's cool!
It's just hard to put that in a cheer.
- [Cheerleaders] We still have basketball! (clapping)
We still have basketball! (clapping)
(cheerleaders sighing)
-------------------------------------------
Check Out We Love You For more infomation >> Check Out We Love You-------------------------------------------
For more infomation >> Check Out We Love You-------------------------------------------
#1 Rated Throwing Set? For more infomation >> #1 Rated Throwing Set?-------------------------------------------
For more infomation >> #1 Rated Throwing Set?-------------------------------------------
5 Injured in N. Falls fire - Duration: 2:04.
HER DAUGHTERS.
WE'RE FOLLOWING BREAKING NEWS IN
NIAGARA FALLS.
FIVE PEOPLE WERE HURT -- WHEN
THEY ESCAPED A BURNING HOME
EARLY THIS MORNING. THEY HAD TO
JUMP FROM THE SECOND FLOOR. NEWS
4'S ALI INGERSOLL IS ON THE
SCENE RIGHT NOW ON FALLS STREET.
WHAT DO WE KNOW RIGHT NOW ALI.
((THEY REPORTED HEAVY VOLUME ON
THE FIRST FLOOR, BASICALLY THE
WHOLE FIRST FLOOR WAS ENGULFED
IN FLAMES, THE ROOF IS CAVED
((THEY REPORTED HEAVY VOLUME ON
THE FIRST FLOOR, BASICALLY THE
WHOLE FIRST FLOOR WAS ENGULFED
IN FLAMES, THE ROOF IS CAVED
IN.....IT'S GOING TO BE A TOTAL
LOSS.))
WHOLE FIRST FLOOR WAS ENGULFED
IN FLAMES, THE ROOF IS CAVED
IN.....IT'S GOING TO BE A TOTAL
LOSS.))
-------------------------------------------
For more infomation >> 5 Injured in N. Falls fire - Duration: 2:04.-------------------------------------------
Learn Colors - SuperHeroes Monster Trucks For Children - Truck Garage Surprise Eggs Cartoon For Kids - Duration: 24:24.
Learn Colors - SuperHeroes Monster Trucks For Children - Truck Garage Surprise Eggs Cartoon For Kids
-------------------------------------------
For more infomation >> Learn Colors - SuperHeroes Monster Trucks For Children - Truck Garage Surprise Eggs Cartoon For Kids - Duration: 24:24.-------------------------------------------
Check Out We Love You For more infomation >> Check Out We Love You-------------------------------------------
'La La Land' Trailer For more infomation >> 'La La Land' Trailer-------------------------------------------
Fiat Punto Evo 1.3 M-Jet Dynamic 5-deurs, 110pk / Airco / Rijklaa - Duration: 1:03.
For more infomation >> Fiat Punto Evo 1.3 M-Jet Dynamic 5-deurs, 110pk / Airco / Rijklaa - Duration: 1:03. -------------------------------------------
Top 10 MakeUp Products Of 2016 SUB ITA - Duration: 13:50.
For more infomation >> Top 10 MakeUp Products Of 2016 SUB ITA - Duration: 13:50. -------------------------------------------
Présentation du Trofinetide par Neuren Pharmaceuticals (sous-titres FR) - Duration: 10:09.Introduction to Neuren.
Neuren Pharmaceuticals is a biopharmaceutical
company, developing new medicines for
diseases and disorders of the central
nervous system or "CNS".
We have four ongoing clinical development programs
on acute conditions : traumatic brain injury
and concussion, and chronic disorders :
Rett syndrome and Fragile X syndrome,
as well as preclinical R&D programs
in a range of other CNS conditions.
Our expert team in Australia,
the US and the UK, includes people with
many years of experience in all aspects of
pharmaceutical development and commercialization.
Neuren shares are traded on the Australian Securities Exchange,
under the code NEU.
What is Trofinetide ?
Trofinetide is the name proposed by the
World Health Organization for our lead
clinical-stage drug candidate.
It is an analog of a molecule, which is derived
from IGF-1 and occurs naturally in the brain.
IGF-1 is a growth factor
stimulated by growth hormone.
In the central nervous system, IGF-1 is produced
by both of the major types of brain
cells : neurons and glia.
IGF-1 in the brain is critical, both
for neural development and for responding
to injury and disease.
In the brain, IGF-1 gets broken down in two separate
molecules : one often referred to as
glypromate - or GPE - comprises the last
three peptides of IGF-1.
GPE affects glial cells, astrocytes and microglia,
while IGF-1 itself mostly affects neurons.
One of the effects of GPE is that
it actually increases production of IGF-1
by neurons and glial cells.
Trofinetide is Neuren's chemically modified
form of GPE, that can mimic GPE's natural
function in the brain.
The small modification results in the drug having
an increased half-life in the circulation,
better stability for easier storage and shipping,
and suitability for use as an oral medication,
whereas GPE itself and
IGF-1 can only be administered by injection.
In the brain, the role of IGF-1 and GPE
is to facilitate the brain's development
and maintain the biological balance
required for normal functioning.
These processes have evolved over millions of years
and are still being extensively
researched by scientists.
During development, the brain and the cells that
make it up change rapidly and in complex ways.
IGF-1 and GPE play a significant
role in regulating these changes.
In the mature brain, IGF-1 and GPE play
an equally important role in responding
to disease, stress and injury.
Whereas most drugs typically exert a
specific effect on a specific target,
Trofinetide exerts diverse effects which
can help to control or normalize
abnormal biological processes in the brain.
Common Pathology Among CNS Disorders
All the different CNS conditions, brain injury,
neurodevelopmental disorders and
neurodegenerative diseases can result in
very different symptoms and outcomes,
many share common underlying
pathological features.
These include : inflammation, overactivation of microglia
(a type of glial cell),
dysfunction of synapses
(the connections between neurons
through which information is transmitted)
and reduced levels of IGF-1.
In other words, diseases and conditions caused by
different mechanisms often result in the
same pathology, at the cellular and
molecular level.
Let's look at these four features.
Inflammation.
Inflammation in the brain,
often referred to as neuroinflammation,
is perhaps the most common pathological
feature of CNS disorders.
Much of it is the result of excess production of
molecules called inflammatory cytokines.
These are prominent in brain injuries,
neurodevelopmental disorders such as
Rett and Fragile X syndromes, as well as
autism, neurodegenerative diseases like
Alzheimer's and Parkinson's and even
so-called normal aging.
Neuroinflammation places significant stress on brain cells.
Stress can disrupt normal cellular processes,
such as information signaling,
increase energy requirements beyond the
ability of the cells to meet their
metabolic needs,
disturb electrical functions which can lead to seizures
and other abnormalities, and even result in
premature cell death.
In animal models, ranging from brain injury and stroke
to Fragile X syndrome to age-associated
cognitive impairment, Trotinetide has
showed an ability to significantly reduce
the levels of inflammatory cytokines.
This has resulted in an improvement in a wide
range of symptoms including
post-traumatic seizures, anxiety,
memory impairment and hyperactivity.
Microglial activation.
Microglia are the resident immune cells in the brain.
Once thought to serve primarily a
sentinel function, responding to
infection and damaged cells by
surrounding and removing them from the
CNS, it is now known that they play a
central role in maintaining synapses
during development and in mature brains
by pruning dendrites (the many small
extensions of neurons that form synapses).
Microglia are also a key source of IGF-1.
Due to this wide-ranging maintenance function,
they have appropriately been
referred to as the "constant gardeners" of
the brain.
Microglia are not only activated in response to
infection and injury.
They are also activated by
inflammation that accompanies acute
brain injury and chronic CNS conditions.
In this activated state, they not only
lose their ability to effectively
perform their normal function in
synaptic maintenance, but also produce
more inflammatory cytokines which can
further compound and damage neurons
and other brain cells.
Trofinetide has been shown to normalize microglial biology
and function, in both acute and chronic conditions.
Restoring normal microglial activity has resulted in
improved synaptic structure as well as correction
of imbalance and synaptic signaling and
cell-to-cell communication.
This has led to reversal of symptoms such as
impaired memory, anxiety, hyperactivity and
compromised social behavior.
Synaptic dysfunction.
Neurons communicate with each other by chemical and
electrical signals transmitted via synapses.
Normal synaptic function is essential for healthy brain function
and underlies memory, cognition, behavior
and other brain activities.
Normal synaptic function requires that
the dendrites (part of the neurons which
form synapses) are appropriately formed
as well as that excitatory and
inhibitory signals are kept in balance.
When dendritic structure and synaptic
signaling are abnormal, virtually all
brain activities can be negatively impacted.
Synaptic dysfunction is then
identified as a core feature of many CNS conditions,
including acute brain injury,
neurodevelopmental disorders and
neurodegenerative diseases.
For example, in Rett syndrome,
dendrites are sparse and immature,
while in Fragile X syndrome,
dendritic branching is excessive
although the dendrites are also immature.
Trofinetide increases the length
and branching of dendrites
in the model of Rett syndrome
while increasing pruning of
excess branching in Fragile X syndrome.
In the Fragile X animal model, aberrant
synaptic signaling was normalized within
15 minutes of the first dose.
IGF-1 dysregulation.
As previously mentioned,
IGF-1 levels in the brain have been
reported to be depressed in a number of
CNS conditions, particularly in Rett and
Fragile X syndromes and brain injury.
In these conditions, the critical role of
IGF-1 and GPE in maintaining and
repairing brain cells and synapses is impaired.
In the Fragile X model, in which
the IGF-1 level is depressed,
Trofinetide increases the amount of IGF-1 to
normal levels.
This was accompanied by normalized synaptic signaling
and complete reversal of cognitive and
behavior abnormalities.
In the model of Rett syndrome,
increasing IGF 1-levels has been
reported to correct deficits in dendritic spines,
and in isolated cells
from human Rett syndrome patients, both
IGF-1 and GPE are able to partially
reverse the deficits in cellular function.
Summarizing, Trofinetide helps to
correct four of the hallmark pathological
features of many CNS disorders :
inflammation, abnormal microglial function,
impared synaptic signaling and
disrupted IGF-1 expression.
By simultaneously targeting multiple
processes, Trofinetide works to restore
the natural balance of brain function.
For more information, please visit our website.
-------------------------------------------
OSAKA JAPAN | 第一次的大阪遊 2016 - Duration: 9:55.
we are going to play the "spiderman" ride
this is the inside of "spiderman"
what did you play just now
spiderman!
how was it
yeah, it's so much better than disney
oh really
why is that
um...it's basically 4D
the visual effect is awesome
it feels like I'm actually falling down
why are you sitting on that
isn't this peeta bro
this is a koala
you think you're spiderman?
where are you?
harry potter section
we are going to go to play the "harrypotter" ride
what are you doing
I'm casting a spell
how come I feel like you're making noodles
playing baseball
why is your wand so ugly
cause you picked it
look what's behind me
what
a castle
a school
is it harry potter's school or a castle
you didn't watch harry potter so you dont know
try it
how is it
compare to 四海遊龍 which one is better
I never tried 四海遊龍 before
then what do you eat in Kaohsiung
八方雲集
which one tastes better
the outer isn't crispy
oh really...
then why is it good
yeah so it's soso
we ordered a lot of flavors
8 flavors
oh wait, 4 flavors
how is it
it's so soft
even the outer is soft?
so, is it good?
everything looks so soft and gooey
yeah, is it not thoroughly cooked yet?
i dont know
so it is yummy?
It feels like I'm eating starch
how is it
the sauce tastes different
wow, the taco is huge
and less starch
comparing to the last one, which one tastes better
this one is better
osaka is so lively
shinsaibashi
wow, it's a standing ramen restaurant
but I heard it's not so delicious
this is sukiyaki meat
I'm eating it with egg
how is it
what are you doing
stir frying cabbages
you're stir frying cabbages in a bbq restaurant
where are we
all you can eat (domestic beef)
is it good
it's better than gyukaku
yeah, so much better than gyukaku
where are you
all you can eat (japanese beef)
super delicious
what is this meat
sukiyaki meat?
you can dip it in egg sauce
let's dig in
which is the most delicious meat
ohh you think is this kind
both are good I think
no, I think one's better than the other
let's look at the desserts
almond tofu
blueberry and cilantro
mine is cilantro, grapefruit, icecream
and raspberry
so did you have a good dinner
absolutely
how many dishes of meat did you eat
so many so many
what is this
this is my dessert
no, you already finished your dessert
and you ate a lot of korean pancakes
-------------------------------------------
RICHEESE FIRE WINGS CHALLENGE (LEVEL 5) Ft. EnjoyAja - Duration: 8:10.
Wihhhh
Hahahaha
Wihhh...
You do it, you do it!
Woahhh!!!
Ok guys, so now we got the Richeese Fire Wings Level 5 challenge man
Ciamikk
With Heni Tania
Affandy
Andri, from enjoyaja.com
Are we ready?
Ready!
Lets do it
Cheers guys
Okay, you first
Ok, sure!
Is it spicy?
Is it spicy?
Nope..
Woeee
Cheers man
Cheers
Cheers guys!
One portion gives you 6 pieces guys
This is just the first one he's tried
We will see how the second piece does
Hahahaha
Yummy!
It's pretty sweet, right?
Sweet.
This seems to be less spicy yeah?
Mie Abang Adek is more spicy, right?
Yeah
This is pretty basic
Is this level 5?
Level 5!
Yes, level 5
This is the witness!
Number one
Yum!
It's getting spicy.
But the chicken wings taste better, yeah?
Chicken wings
Tastes good, yeah?
Not using the cheese sauce?
Later on, for the last piece we will use the cheese
The last one we're allowed to use the cheese
Two.
He's strong with the spices, yeah?
Strong.
Those two at Mie Abang Adek, woah..
Awesome.
So dangerous if your hands touch your eyes
Affandy, can you see this?
Nooo!
Hahahaha
He's enjoying the food
It's starting to get spicy, yeah?
The spice is in the mouth
Yeah?
Yeah.
Is it starting to get spicy for you?
No big deal.
We can starting eating the cheese sauce now right?
Yeah. Take it.
It's a pity if we don't eat it
Actually, the thing that makes it taste yum is the cheese
Ciamik!
Are my lips red yet?
Yup.
Your lips are already red
The heat is all over my lips
Last one
Let's use the cheese as well, man!
Oh damn, look how good that looks, man.
Love it.
Woah, he's good. He went straight for the cheese
I wasn't strong without using the cheese
Yeah, hes good with the heat
Cheers!
Hahahah
It's already finished!
It's already finished, man!
It's not that spicy, but it tastes good!
But his bones are so clean!
We have to clean the bones, yeah?
Yay, I finished!
Not yet.
There is still so much meat!
Hahahaha
Turns out he is strong with the heat, right?
Beautiful.. Beautiful.
This time, he wins.
I wanna enjoy the cheese sauce
Cheers!
Now we have a little drink..
Still strong Affandy?
Andri, okay?
I'm getting the sniffles
Turns out he's strong with the heat, yeah?
Or was he just pretending not to be?
But he's sweating, yeah?
No la!
But you were sweating!
Because it was hot
Finished!
The cheese is yummy, yeah?
Yum, right?
Andri's done.
Affandy, just a bit more!
Richeese Fire wings level 5
Red lips, red lips
It's like you're using lip stick, right
Alright thats the Richeese challenge
Richeese Fire Wings level 5 challenge
We've all done it
Ciamik!
Beautiful.
Already drank
She must come here a lot
Good, yeah
We've only had it twice
But we only ate 3 fire wings
Yeah, only 3
And I was like..
Just to try it out
The first time we tried it out, our lips were so red
Your lips are the reddest
Yeah!
His lips are starting to get red
Oh yeah, yeah, yeah
Guys, my lips are red, guys
Hahahahaha
I was wrong because I put the sauce on my lips
You should just put it straight into your mouth
You still have sauce on your mouth
I hope you guys enjoyed that Richeese Fire Wings Challenge
Level 5
Make sure you guys subscribe over at enjoyaja.com
Yes! Ciamik!
With Affandy, Andri. Wonderful people
I hope you guys enjoy their stuff
They're beautiful, wonderful people
And we will see you again soon
For a challenge, another spicy challenge
See you guys soon!
Yeah!!!
I'm crying
-------------------------------------------
Aches And Pains Osteoarthritis Arthritis Or Joint Pain Natural Medicine - Duration: 10:04.
Secret Tree of Pain Medication Cure Bone End a Match After 5 days revealed that all medicine osteoarthritis pain stopped after 5 days by scratching trees very few people know. Today Banana Health will reveal this secret to all of you! Secret Tree of Pain Medication Cure Bone End a Match Next 5 Days is revealed
-------------------------------------------
Finally approched 1000 subscribers! happy video - Duration: 5:44.
What? I finally got over 1000 subscribers..!?
Hi guys!
I can't believe it! The number of subscribers approached over 1000 !
(One of my subscribers said in a comment, my dad and I are so funny together.)
(acting like being indiffernt)
PLEASE TELL SOMETHING TO MY SUBSCRIBERS ~
Dad says no, because of my voice. (I agree about the reason now)
Then, tell me something good about my future.
-Just eat dinner.
Pleeease, tell me something!
-For your future? Yes.
-Be voluptuous.
what? voluptuous?
Then I have to be borned one more time.
-I didn't mean that. I want your future to be plentiful.
Ahh, I got it. But your vocabulary choice is a bit strange.
-Please pass by me.
-Because I don't have any make up on.
I will blurr. It's okay.
-Please blurr me too.
No I won't. I have uploaded your actions already.
I'll think what to say. Maybe next time.
Anyway,
I really really appreciate it.
-Why do you talk like that ridiculous way?
Then, let me talk pretty normal way.
(Still ridiculous-Fail..)
-Just come here and eat your meal.
No, I'm not hungry yet.
Because..
-The most important thing to you is studying.
NO.
I'm full because..
I'm eating all of you guys' love haha
I'm so full every seconds.
(Please anybody get rid of eyeshadows stuck in my inner eyelids.)
Why am I talking like this every moment in front of camera?
(I'm explaining the reason. Because I watched someone's video, and I'm overdosed)
I'm filming this video in hurry
because I noticed this(subscribers).
(Almost crying)
Thank you so much.
I'll upload a number of contents.
about my funny life.
I'll go for it!
And my next video will be uploaded tomorrow. (2016.12.30)
Please wait for the video.
(finger heart)
What's wrong with me?
I want to film self video normally.
Look at this cuty ear ring!
(Being normal-Fail)
I bought these in christmas market.
I love it.
Anyway, again thank you guys.
shadow shadow
Video of appreciating.
(Look at my ring finger)
Then, see in you next video. Bye~
(Get ready for funny dance and lip sink)
♬Jay Park-All I Wanna Do♬
♬BlackPink-Whistle♬
? haha
♬Jay Park-Me like Yuh♬
Thanks all my subscribers!
(Stairs motion)
(Escalator motion)
(Thanks for watching this video. And please wait for the next video. Bye~)
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